%0 Journal Article
%T Studying Alzheimer¡¯s Disease Using <i>Drosophila melanogaster</i> as a Powerful Tool
%A Jacob Kasanin
%A Xingjun Wang
%A Wanting Jiao
%A Qiuyu Li
%A Bingwei Lu
%J Advances in Alzheimer's Disease
%P 23-37
%@ 2169-2467
%D 2022
%I Scientific Research Publishing
%R 10.4236/aad.2022.113003
%X <strong>Ba</strong><strong>ckground</strong><strong>:</strong> Alzheimer¡¯s disease (AD) is an increasingly prevalent neurodegenerative disease characterized by protein aggregation in the form of amyloid plaques containing beta-amyloid peptides and neurofibrillary tangles containing hyperphosphorylated tau protein. The central molecular events underlying AD pathogenesis remain controversial and poorly defined. <em>Drosophila melanogaster</em> has emerged as an important genetic resource for studying the pathology of AD. Many AD models have been created using <em>Drosophila</em>, taking advantage of its short generation times, sophisticated genetic tools, and abundance of homologs to human genes. <strong>Purpose:</strong> This review summarizes different models for studying AD in <em>Drosophila melanogaster</em>, including the full-length APP, C99, A<em>¦Â</em>42 and Tau models, explaining how the models were built and what we have learned from them. <strong>Conclusion:</strong> Four main AD <em>Drosophila</em> models are introduced in this review, which can serve as a future method to investigate genes and drugs that can modify symptoms.
%K &lt
%K i&gt
%K Drosophila&lt
%K /i&gt
%K Alzheimer¡¯s Disease
%K APP
%K C99
%K A&lt
%K i&gt
%K ¦Â&lt
%K /i&gt
%K 42
%K Tau
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=120505