%0 Journal Article
%T Neuro-Cognitive Functions in ALL Childhood Cancer Survivors in NCI, Cairo University, Egypt
%A Menna Shamma
%A Ahmed Kamel
%A Doaa R. Ayoub
%A Mohamed H. Fawzy
%J Open Access Library Journal
%V 9
%N 10
%P 1-13
%@ 2333-9721
%D 2022
%I Open Access Library
%R 10.4236/oalib.1109337
%X Objective: Acute Lymphoblastic Leukemia (ALL) is one of the most common childhood malignancies, accounting for about 75% of all leukemias and a quarter all of childhood cancers, in this research we aimed at assessing neuro-cognitive consequences in children with Acute Lymphoblastic Leukemia who have been treated with chemotherapy. Methods: 95 children aged between 6 and 12 years old completed Wechsler Intelligence Scale for Children (WISC III). Sixty-one children were ALL survivors at the Pediatric Oncology Department, NCI, Cairo University compared to thirty-four were control group consisted of matching children from the same age group. Study patients have successfully accomplished their treatment protocol and were in complete remission during the evaluation for ¡Ý 2 years under follow up without relapse and no prediagnosis history of neuro-developmental disorder nor psychiatric disorders as evidenced by Child Behaviour Checklist (CBCL). Results: Subjects scored significantly below levels for their matched controls. The difference between patients and controls was significant (p < 0.001) for the following measures: Total IQ, Verbal IQ, Performance IQ scores, (84.8 ¡À 10 vs. 98.7 ¡À 10.3), (94.4 ¡À 13.5 vs. 110.1 ¡À 13.6) and (76.6 ¡À 10 vs. 85.5 ¡À 8.5) respectively. Sex was considered a risk factor where females performed worse than males in verbal IQ with significance (p-value = 0.045). Conclusions: Long-term sequels in neuro-cognitive functions were found in the chemotherapy only group, female patients were at higher risk than males; observed in the impairments of memory, attention, logical thinking and social knowledge.
%K Acute Lymphoblastic Leukemia
%K Neuro-Cognitive Functions
%K Child Behavior Checklist
%K Chemotherapy
%K Wechsler Intelligence Scale
%U http://www.oalib.com/paper/6782378