%0 Journal Article
%T CD4<sup>+</sup> T细胞能量代谢在神经系统自身免疫性疾病中的研究进展<br>Research Progress of CD4<sup>+</sup> T Cell Energy Metabolism in Autoimmune Diseases of the Nervous System
%A 齐崇志
%A 冯勋刚
%J Advances in Clinical Medicine
%P 8162-8169
%@ 2161-8720
%D 2022
%I Hans Publishing
%R 10.12677/ACM.2022.1291176
%X CD4<sup>+</sup> T细胞在机体免疫系统中具有重要作用，根据活化后的功能不同可分为辅助性T细胞(T helper cells, Th)和调节性T细胞(regulatory T cells, Treg)，Th包括Th1、Th2、Th9、Th17、Th22等亚群。CD4<sup>+</sup> T细胞在发育、激活和介导免疫应答等过程中均会进行代谢重编程，以满足其对应的能量需求，CD4<sup>+</sup> T细胞能量代谢异常会导致机体免疫功能紊乱，在自身免疫性疾病中发挥重要作用。本文主要对CD4<sup>+</sup> T细胞亚群能量代谢异常与自身免疫性疾病相关研究进展进行综述。<br />
CD4<sup>+</sup> T cells play an important role in the body’s immune system. According to different functions after activation, they can be divided into helper T cells (T helper cells, Th) and regulatory T cells (Treg). Th includes Th1, Th2 , Th9, Th17, Th22 and other subgroups. CD4<sup>+</sup> T cells undergo metabolic reprogramming during development, activation, and mediating immune responses to meet their corresponding energy needs. Abnormal energy metabolism of CD4<sup>+</sup> T cells can lead to immune dys-function and play an important role in autoimmune diseases. This article mainly reviews the re-search progress of abnormal energy metabolism of CD4<sup>+</sup> T cell subsets and autoimmune diseases.
%K CD4<sup>+</sup> T细胞，能量代谢，自身免疫性疾病<br>CD4<sup>+</sup> T Cells
%K Energy Metabolism
%K Autoimmune Disease
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=55531