%0 Journal Article
%T 乌拉地尔的有效制备<br>Effective Preparation of Urapidil
%A 周德军
%A 马文龙
%A 盛遵田
%A 刘发文
%J Hans Journal of Medicinal Chemistry
%P 275-286
%@ 2331-8295
%D 2022
%I Hans Publishing
%R 10.12677/HJMCe.2022.103028
%X 本文介绍一种盐酸乌拉地尔的有效工业合成法。乌拉地尔是临床常用的一种降压药物，合成研究已被多个研究团队报道。本团队采用氨基尿嘧啶为起始原料，经胺胺交换、氯代、亲核取代、盐酸成盐、重结晶共5步得到盐酸乌拉地尔，总收率达48.94%，纯度99.9%以上。本文详细阐述了合成盐酸乌拉地尔的工艺流程，为今后工业生产提供准确详实的参考。<br />
This paper introduces an efficient industrial synthesis method of urapidil hydrochloride. Urapidil is a commonly used antihypertensive drug in clinic, and its synthesis research has been reported by several research teams. Our team used aminouracil as the starting material, and obtained urapidil hydrochloride through 5 steps of amine-amine exchange, chlorination, nucleophilic substitution, hydrochloric acid salt formation, and recrystallization, the total yield is 48.94%, and the purity is above 99.9%. This paper expounds the technological process of synthesizing urapidil hydrochloride in detail, and provides accurate and detailed reference for future industrial production.
%K 乌拉地尔，氨基尿嘧啶，降压药，工艺流程<br>Urapidil
%K Aminouracil
%K Antihypertensive Drug
%K Synthesis Process
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=55095