%0 Journal Article
%T Image Quality Assessment Using NEMA Standards for Lu-177 Radionuclide
%A Olivia Adu-Poku
%A Bright Kwakye-Awuah
%A Eric Kotei Addison
%A Stephen Inkoom
%J International Journal of Medical Physics,Clinical Engineering and Radiation Oncology
%P 125-134
%@ 2168-5444
%D 2022
%I Scientific Research Publishing
%R 10.4236/ijmpcero.2022.113011
%X A lutetium 177 (<sup>177</sup>Lu)
radiopharmaceutical has been used </span><span style=\"font-family:&quot;\">as</span><span style=\"font-family:&quot;\"> a theragnostic agent in molecular radiotherapies. This study aimed to
produce images simulating those obtained in a total body imaging study with hot
lesions to assess and investigate the image quality of the Hawkeye SPECT/CT
images from Lu-177. The NEMA image quality phantom (PTW) with spheres (inner
diameters of 10, 13, 17, 22, 28 and 37 mm) and lung insert was used. </span><span style=\"font-family:&quot;\">The </span><span style=\"font-family:&quot;\">measured volume in </span><span style=\"font-family:&quot;\">the </span><span style=\"font-family:&quot;\">background of </span><span style=\"font-family:&quot;\">the </span><span style=\"font-family:&quot;\">current phantom setting was
9482 mL. The five smaller spheres were filled with </span><span style=\"font-family:&quot;\">an </span><span style=\"font-family:&quot;\">activity concentration of 0.461 MBq/mL and the biggest
sphere </span><span style=\"font-family:&quot;\">was </span><span style=\"font-family:&quot;\">filled with water. The phantom was placed on the couch </span><span style=\"font-family:&quot;\">and </span><span style=\"font-family:&quot;\">scanned at four hot
sphere-to-background concentrations, which </span><span style=\"font-family:&quot;\">are</span><span style=\"font-family:&quot;\"> no background, 16:1, 8:1 and 4:1. The images
obtained from the scans were imported onto the OXIRIS image analysis tool.
Regions of interest (ROIs) were drawn on each sphere of the reconstructed SPECT
image. </span><span style=\"font-family:&quot;\">Image contrast and background
variability ratios for hot spheres were used as measures of image quality. In
addition, the accuracy of corrections w</span><span style=\"font-family:&quot;\">ere</span><span style=\"font-family:&quot;\"> determined from the uniform
background and cold lung insert regions. The 37 mm cold sphere had the highest
percent contrast</span><span style=\"font-family:&quot;\">,</span><span style=\"font-family:&quot;\"> whiles the 10 mm hot sphere had the least for the
various hot sphere to background ratios. The background variability for each
hot sphere was also determined. The average lung residual error was calculated
to be 23.13% for the 16:1 and 22.57% for both the 8:1 and 4:1 hot sphere to
background ratio. The results show that the scanner has very good overall
performance.
%K Lutetium-177
%K Activity Concentration
%K Dose Calibrator
%K SPECT/CT
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=118359