%0 Journal Article
%T Multiple Myeloma: Modification and Adaptation of Plasma Cell Morphology Algorithm for the Prognosis of Congolese Patient
%A Jean Pierre Mufuta Ntolo
%A Ritha Nyembu Kibambe
%A Luc Kapia Lunkamba
%A Paola Bilonda Kalonji
%A Blaise Sumbu
%A Gustave Ilunga Ntita
%A Jean Marie Mbuyi Muamba
%A J¨¦r¨¦mie Muwonga Madidi
%A Donatien Kayembe Nzongola
%J Open Journal of Blood Diseases
%P 29-38
%@ 2164-3199
%D 2022
%I Scientific Research Publishing
%R 10.4236/ojbd.2022.122003
%X <b><span style=\"font-family:Verdana;\">Objectives: </span></b><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">To determine the multiple myeloma (MM) prognostic
formulas applicable in Congolese with many aberrant and/or immature plasma
cells according to GOASGUEN¡¯s plasma cell morphology algorithm (PMA). </span><b><span style=\"font-family:Verdana;\">Methods: </span></b><span style=\"font-family:Verdana;\">The prospective, observational and descriptive study was carried out at the
Ngaliema Clinic in Kinshasa from July 2016 to December 2019. The va</span><span style=\"font-family:Verdana;\">riables studied were the plasma cell types and the
prognosis groups accordin</span><span style=\"font-family:Verdana;\">g to GOASGUEN and ZANDECKI. </span></span><span style=\"font-family:Verdana;\">The nucleolus, the
chromatin and the N/C ratio of 2 for each plasma cell encountered in multiple
myeloma are examined in order by asking three successive questions as follows:
1) Is the nucleolus present? If yes, we denote 1; if not, note 0; 2) Is the
chromatin thin? If yes, we score 1; if not we score 0; 3) The N/C ratio is greater
than 6, if so, 1 is noted; if not, we note 0. We obtain a number with 3
successive digits preceded by the letter P for each plasma cell.</span><span style=\"font-family:&quot;\"> </span><b><span style=\"font-family:Verdana;\">Results: </span></b><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">The
overall rate of immature plasma cells and aberrant plasma cells in MM among
Congolese was high at 26.6%. Their integration in the prognostic formulas
showed for group A\" = 22 patients, group B\" = 5 patients and group
C\" = 32 patients. Examination of plasma cell types in the deceased showed
that 14/17 had a P001 plasma cell count ¡Ý 15%. </span><b><span style=\"font-family:Verdana;\">Conclusion: </span></b><span style=\"font-family:Verdana;\">The high rate
of aberrant and/or immature plasma cells, the P001 plasma cell type at a rate ¡Ý
15%, found mostly in group C\" with poor prognosis, are responsible for the
aggressive nature of MM in Congolese Blacks.
%K Plasma Cell Morphology Algorithm
%K Plasma Cell Types
%K Aberrant Plasma Cells
%K Immature Plasma Cells
%K Multiple Myeloma
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=118117