%0 Journal Article %T CO2点阵激光联合他克莫司治疗白癜风的疗效与安全性Meta分析
Meta-Analysis on the Efficacy and Safety of CO2 Fractional Laser Combined with Tacrolimus in the Treatment of Vitiligo %A 沈旭 %J Advances in Clinical Medicine %P 4621-4627 %@ 2161-8720 %D 2022 %I Hans Publishing %R 10.12677/ACM.2022.125667 %X 目的:系统评价CO2点阵激光联合他克莫司治疗白癜风的疗效和安全性。方法:在Cochrane Library、PubMed、Embase、CNKI、VIP、Wanfang data、CBM检索,得到CO2点阵激光联合他克莫司治疗白癜风相关文献,按制定标准筛选后,用Revman5.3软件分析。结果:共9篇随机对照试验,含694例白癜风患者,以有效率为疗效指标。Meta分析结果为RR = 1.30,95% CI (1.21, 1.40),Z = 7.17,P < 0.00001,表示CO2点阵激光联合他克莫司治疗白癜风的有效率高于单用他克莫司;不良反应发生率无明显差异。结论:CO2点阵激光联合他克莫司与单用他克莫司相比治疗白癜风效果更好,且安全性佳,无显著不良反应。
Objective: To systematically evaluate the efficacy and safety of CO2 fractional laser combined with tacrolimus in the treatment of vitiligo. Methods: Literature related to the treatment of vitiligo with CO2 fractional laser combined with tacrolimus were retrieved from Cochrane Library, PubMed, Em-base, CNKI, VIP, Wanfang data and CBM. After screening according to the established standards, Revman5.3 software was used for analysis. Results: There were 9 randomized controlled trials in-volving 694 patients with vitiligo. The effective rate was taken as the curative effect index. The re-sults of meta-analysis were RR = 1.30, 95% CI (1.21, 1.40), Z = 7.17, P < 0.00001, indicating that CO2 fractional laser combined with tacrolimus was more effective than tacrolimus alone in the treat-ment of vitiligo. There was no significant difference in the incidence of adverse reactions. Conclu-sion: CO2 fractional laser combined with tacrolimus has better efficacy and safety than tacrolimus alone in the treatment of vitiligo, with no significant adverse reactions. %K 白癜风,点阵激光,他克莫司,Meta分析
Vitiligo %K Fractional Laser %K Tacrolimus %K Meta-Analysis %U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=51891