%0 Journal Article
%T 电化学催化1,4-萘醌的双官能团化反应构建碘代氨基萘醌化合物<br>Synthesis of Iodoaminonaphthoquinone Compounds by Electrochemically Catalyzed Bifunctionalization of 1,4-Naphthoquinone
%A 徐雪
%A 何永辉
%J Hans Journal of Chemical Engineering and Technology
%P 194-200
%@ 2161-8852
%D 2022
%I Hans Publishing
%R 10.12677/HJCET.2022.123027
%X 氨基萘醌类化合物是一类具有重要生理活性的杂环化合物，广泛存在于天然产物的结构中。因此，高效构建该类化合物具有重要的意义。本文以碘化钠为媒介，在电化学条件下实现了1,4萘醌的双官能团化反应，以33%~70%的收率得到了8种含不同取代基的碘代氨基萘醌类化合物，并通过自由基捕获实验验证该反应可能涉及自由基机理。<br />
Aminonaphthoquinones widely exist in natural products and have good biological activities. The synthesis of this kind of compounds has always been a hotspot for scientists. In this work, iodoaminonaphthoquinones with different substituents were synthesized by the bifunctionalization of 1,4-naphthoquinone in the medium of sodium iodide under electrochemical conditions. Through oxidation additions, eight iodoaminonaphthoquinones with different substituents were synthesized in 33%~70% yield under the optimal conditions. The free radical capture experiment verified that the reaction may involve the free radical mechanism.
%K 1&#184
%K 4萘醌，双官能团化，电催化<br>1&#184
%K 4-Naphthoquinone
%K Bifunctionalization
%K Electrocatalysis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=51993