%0 Journal Article
%T Salivary Active MMP-2 of Breast Cancer Patients Is Inhibited by Guava Leaves PBS Extract
%A Ramanuj Mukherjee
%A Syandan Sinha Ray
%A Subhajit Mondal
%A Amitava Chatterjee
%J American Journal of Plant Sciences
%P 650-658
%@ 2158-2750
%D 2022
%I Scientific Research Publishing
%R 10.4236/ajps.2022.135043
%X Matrixmetalloproteinase-2 (MMP-2), also called
gelatinase-A, is a 72 Kd protein present in chromosome 16 in human. It is a
zinc binding protein, responsible for the degradation of Extra Cellular Matrix
(ECM) in normal physiological as well as disease processes like arthritis and
cancer. It has a specific role in the cancer development and angiogenesis.
MMP-2 contributes to cell migration. MMPs are the key to normal development as
well as in the pathology of cancer and other inflammatory diseases. The
inhibitors of MMP-2 activity are very important in maintaining the normal
activity of MMP-2 and have an important role in the management of cancer.
Regulation of MMP-2 activity is done by inhibitors like, TIMPs. In this report,
we are discussing about a possible inhibitor(s) present in the PBS extract of
guava leaves, inhibiting the active MMP-2 present in the saliva of breast
cancer patients.
%K MMP-2
%K Inhibitor
%K Saliva
%K Breast Cancer
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=117456