%0 Journal Article
%T 高迁移率族蛋白1在白癜风中的研究进展<br>Research Advances of HMGB1 in Vitiligo
%A 冯丁夏
%A 肖异珠
%J Hans Journal of Biomedicine
%P 143-149
%@ 2161-8984
%D 2022
%I Hans Publishing
%R 10.12677/HJBM.2022.123018
%X 白癜风发病机制复杂，涉及多种学说。氧化应激和自身免疫作为白癜风形成与发展的重要机制，两者相互影响，贯穿疾病整个进程的始终。现有研究表明，部分黑素细胞特异性自身免疫的活化由氧化应激诱发。高迁移率族蛋白1作为氧化应激与自身免疫联系的重要分子，近来被发现参与白癜风发病过程。本文将结合近年来的研究进展，对高迁移率族蛋白1在白癜风发病中的作用进行综述，为靶向治疗提供新的突破点。<br />
The pathogenesis of vitiligo is complex and involves many theories. As the important mechanisms of vitiligo occurrence and progression, oxidative stress and autoimmunity influence each other throughout the whole process of the disease. Existing studies suggest that some melanocyte-specific autoimmunity activation is induced by oxidative stress. HMGB1, as important molecule that links oxidative stress and autoimmunity, has recently been found to be involved in the pathogenesis of vitiligo. This article will briefly review the research progress on the role of HMGB1 in vitiligo to provide a breakthrough for targeted therapy.
%K 高迁移率族蛋白1，白癜风，发病机制<br>HMGB1
%K Vitiligo
%K Pathogenesis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=51271