%0 Journal Article
%T Pd-Catalyzed Unprecedented Cross-Coupling of Mixed Phenols and Halides for the Synthesis of Aromatic Ethers
%A Mohammad Al-Masum
%A Reem M. Albeshy
%A Houra A. Alalwan
%J International Journal of Organic Chemistry
%P 75-91
%@ 2161-4695
%D 2022
%I Scientific Research Publishing
%R 10.4236/ijoc.2022.122007
%X Phenolic compounds present in medicinal and edible plants such as</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">flavonoids, chalcones,
coumarins, quinones, </span><span style=\"font-family:Verdana;\">and </span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">phenolic acids. The antioxidant potential of phenolic compounds shows
potent activities for cancer prevention </span><span style=\"font-family:Verdana;\">and
its treatment. </span></span><span style=\"font-family:Verdana;\">From</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">a </span><span style=\"font-family:Verdana;\">green chemistry point of view, cascade (tandem) reac</span><span style=\"font-family:Verdana;\">tions are ideal techniques in
organic synthesis for building complex structures. Cascade techniques </span><span style=\"font-family:Verdana;\">are </span><span style=\"font-family:Verdana;\">sometimes observe</span><span style=\"font-family:Verdana;\">d</span><span style=\"font-family:Verdana;\"> in
coupling reactions under </span><span style=\"font-family:Verdana;\">mild conditions with </span><span style=\"font-family:Verdana;\">a </span><span style=\"font-family:Verdana;\">tolerance of multifunctional groups. It will be
interesting to find a cascade type reaction to synthesize polyphenolic ethers.
This research project achieves a new cross-coupling method for establishing
polyphenolic ethers from mixed phenols and halides in the presence of palladium
catalyst in moderate to good yields.
%K Microwave
%K Ethers from Mixed Phenols
%K Cross-Coupling
%K Cascade Type Reac-tion
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=117168