%0 Journal Article
%T Bronsted酸催化串联反应一锅制备3-氨基-1-茚酮<br>Bronsted Acid-Catalyzed One-Pot Synthesis of 3-Aminoindan-1-Ones through a Domino Reaction
%A 翟伍超
%A 刘家璇
%A 闫佳玉
%A 杜美烨
%A 吕新
%A 康红兰
%J Journal of Organic Chemistry Research
%P 39-49
%@ 2330-524X
%D 2022
%I Hans Publishing
%R 10.12677/JOCR.2022.102004
%X 本文主要研究了在有机Bronsted酸催化条件下，由邻乙炔基苯甲醛与环状脂肪仲胺经烯胺化/环化/水解串联反应一锅合成3-氨基-1-茚酮类化合物。该方法具有原料易得、底物适用范围广(各种取代的邻乙炔苯甲醛和环状仲胺均可顺利参与)、产率高(81%~97%)、时间较短(5~9 h)、可放大量制备(20 mmol规模)、一锅合成方式操作便捷等优势。<br />
The paper demonstrates the one-pot synthesis of 3-aminoindan-1-ones through the domino enamidation/cyclization/hydrolysis reactions between o-ethynylbenzaldehydes and cyclic aliphatic amines under organic Bronsted acid catalysis. This method possesses many merits, such as the readily available starting materials, broad substrate scope (various substituted o-ethynylbenzaldehydes and cyclic aliphatic amines participated in the reaction successfully), high yields (81%~97%), short reaction time (5~9 h), scalability (20 mmol scale), and convenient one-pot synthetic procedures.
%K 3-氨基-1-茚酮，酸催化，串联反应，邻炔基苯甲醛，一锅合成<br>3-Aminoindan-1-One
%K Acid-Catalyzed
%K Domino Reaction
%K O-Ethynylbenzaldehyde
%K One-Pot Synthesis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=50402