%0 Journal Article
%T 子宫内膜容受性标志物与体外受精胚胎移植反复种植失败的相关性研究<br>Correlation between Endometrial Receptivity Markers and Repeated Implantation Failure of IVF-ET
%A 金锐
%A 马文叶
%A 唐大伟
%A 刘芳
%A 包俊华
%A 白刚
%J Advances in Clinical Medicine
%P 3471-3474
%@ 2161-8720
%D 2022
%I Hans Publishing
%R 10.12677/ACM.2022.124503
%X 探讨子宫内膜容受性(Endometrial receptivity, ER)标志物血管内皮生长因子(Vascular Endothelial Growth Factor, VEGF)、胰岛素样生长因子(Insulin-like Growth Factor, IGF)、白细胞因子(Human Leukemia Inhibitory growth factor, LIF)等在反复种植失败患者(Repeated implantation failure, RIF)子宫内膜种植窗期的表达与妊娠的相关性。方法：收集银川市妇幼保健院生殖中心2018年1月~2021年10月行体外受精–胚胎移植(In vitro fertilization-embryo transfer, IVF-ET)治疗的152例患者的种植窗期子宫内膜组织。采用免疫组化(immunohistochemistry)法检测RIF患者(RIF组，n = 82)和成功妊娠患者(对照组，n = 70) VEGF、IGF、LIF在种植窗期的表达水平。结果：RIF组种植窗期ER标志物VEGF、IGF、LIF的表达均低于对照组，其中VEGF的表达明显低于对照组(P &lt; 0.05)。结论：种植窗期子宫内膜VEGF、IGF、LIF的表达有降低的趋势，与RIF的发生具有一定的相关性。<br />
Objective: To investigate the expression of ER markers VEGF, IGF, LIF implantation window stage and their correlation with RIF. Methods: 152 cases of IVF-ET endometrial tissues in implantation window stage were collected from Yinchuan maternal and child health hospital from Jan. 2018 to Oct. 2021. The expression levels of VEGF, IGF, LIF in patients with RIF (RIF group, n = 82) and patients with successful pregnancy (control group, n = 70) were detected by immunohistochemistry. Spearman correlation was used to analyze the relationship between VEGF, IGF, LIF, in RIF group. Results: At the implantation window stage, the levels of VEGF, IGF, LIF in RIF group were lower than those in the control group (P &lt; 0.05). The levels of VEGF were lower significantly (P &lt; 0.05). Conclusion: VEGF, IGF, LIF are expressed in planting window stage. The decrease of VEGF, IGF and LIF in the implantation window is closely related to RIF.
%K 子宫内膜容受性，反复种植失败，种植窗<br>Endometrial Receptivity
%K Repeated Implantation Failure
%K Planting Window
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=50891