%0 Journal Article
%T CAR-T疗法在胃癌中的研究进展<br>Progress of CAR-T Therapy in Gastric Cancer
%A 李桃
%A 崔童
%A 王建华
%J Advances in Clinical Medicine
%P 2500-2509
%@ 2161-8720
%D 2022
%I Hans Publishing
%R 10.12677/ACM.2022.124361
%X 继嵌合抗原受体T细胞(chimeric antigen receptor T cell, CAR-T)免疫疗法在血液系统肿瘤中取得显著成效之后，CAR-T疗法用于实体瘤亦逐渐成为研究热点。胃癌(GC)是最常见的消化道恶性肿瘤之一，是全球第三大癌症相关死亡原因。对于缺乏手术适应症及放疗、化疗效果不好的患者，迫切需要寻找新颖而高效的治疗方式。CAR-T疗法在胃癌的治疗中已取得一些成果，不过也存在一些需要克服的障碍。本文综述了CAR-T疗法在胃癌中的治疗现状及面临的挑战。<br />
Since chimeric antigen receptor T-cell (CAR-T) immunotherapy has achieved remarkable results in hematological tumors, CAR-T therapy has gradually become a hot topic in solid tumors. Gastric cancer is one of the most common types of cancer and the third leading cause of cancer-related death overall. It is urgent to find novel and efficient treatment methods for patients who lack surgical indications or those who with poor radiotherapy and chemotherapy outcomes. CAR-T therapy has made some achievements in the treatment of gastric cancer, but there are still some obstacles to overcome. This paper reviews the current status and challenges in CAR-T therapy for gastric cancer.
%K 嵌合抗原受体T细胞，胃癌，免疫治疗<br>Chimeric Antigen Receptor T Cell
%K Gastric Cacer
%K Immunotherapy
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=50009