%0 Journal Article
%T γ-谷氨酰转肽酶促氧化作用在肿瘤进展和顺铂耐药中的研究进展<br>Review of Research on Gamma-Glutamyl Transferase Pro-Oxidant Effects in Tumor Progression and Cisplatin Resistance
%A 沐宇
%A 彭瑞
%A 梁兴忠
%A 王威
%A 吴昕雨
%A 赵苗苗
%A 石祥奎
%A 黄亭
%J World Journal of Cancer Research
%P 33-41
%@ 2164-9057
%D 2022
%I Hans Publishing
%R 10.12677/WJCR.2022.122005
%X γ-谷氨酰转移酶(Gamma-glutamyl transferase, GGT)是参与谷胱甘肽代谢的关键酶，在恶性肿瘤中通常过表达。GGT在肿瘤细胞中的诱导、表达等过程十分复杂。早期的研究主要集中在GGT的细胞抗氧化防御功能，近年来GGT的促氧化活性逐渐被发现。GGT的促氧化剂可以调节细胞功能，如增殖/凋亡平衡，在肿瘤进展和耐药性方面具有明显而重要的意义。本文对近期关于γ-谷氨酰转移酶在肿瘤进展和顺铂耐药中的研究进行综述。<br />
Gamma-glutamyl transferase (GGT) is a key enzyme involved in glutathione metabolism, whose expression is often significantly increased in human malignancies. The induction and expression of GGT in tumor cells are very complex. Early studies on GGT focused on antioxidant defense function. In recent years, the pro oxidative activity of GGT has been gradually found which can regulate cell function such as proliferative/apoptotic balance with great significance in tumor progression and drug resistance. This paper reviews the recent research on Gamma-glutamyl transferase in tumor progression and cisplatin resistance.
%K γ-谷氨酰转移酶，肿瘤，氧化还原，顺铂，耐药<br>Gamma-Glutamyl Transferase
%K Tumour
%K Redox
%K Cisplatin
%K Drug Resistance
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=49995