%0 Journal Article
%T 2018~2020年大理市某医院无乳链球菌感染分布及耐药性分析<br>Distribution and Drug Resistance Analysis of S. agalactiae Infections in a Hospital in Dali City, 2018~2020
%A 张杰
%A 汤绍波
%A 李志敏
%A 徐佳琪
%A 樊玉娟
%J Advances in Clinical Medicine
%P 2444-2450
%@ 2161-8720
%D 2022
%I Hans Publishing
%R 10.12677/ACM.2022.124353
%X 目的：探讨大理大学第一附属医院无乳链球菌的临床分布特点、耐药特性以及其变化趋势，为临床用药治疗和预防提供参考。方法：收集2018~2019年大理大学第一附属医院门诊和住院患者的各类临床标本，并对其进行分离培养、细菌鉴定、药敏试验和结果判定。结果：2018~2020年我院共分离出无乳链球菌267株，科室分布主要集中于产科(46.07%)、妇科(31.46%)；标本主要来源于分泌物(84.27%)，其次是中段尿(7.49%)和痰液(3.00%)；年龄在18~60岁患者占比最多(86.89%)；感染无乳链球菌的患者中女性占87.27%；在267株无乳链球菌中，对恶唑烷酮类利奈唑胺、替加环素和阿莫西林的耐药性均为0%，头孢孟多耐药性为91.32%，左氧氟沙星耐药性为47.92%，四环素耐药性为76.81%，莫西沙星耐药性为47.92%，呋喃妥因耐药性为7.92%，环丙沙星耐药性为20%，阿奇霉素耐药性为28.30%，青霉素和万古霉素的耐药性均0.38%。结论：2018~2020年我院共检出无乳链球菌267株，主要是从分泌物标本中分离出，易感人群主要是18~60岁的女性，特别是育龄期妇女居多。通过分析数据，发现头孢孟多和四环素不建议用于治疗被无乳链球菌感染的患者；替加环素、恶唑烷酮类利奈唑胺和阿莫西林建议作为无乳链球菌感染患者的一线药物。<br />
Objective: To explore the clinical distribution characteristics, drug resistance characteristics and the trend of Streptococcus agalactiae in the First Affiliated Hospital of Dali University, and to provide reference for clinical treatment and prevention. Methods: Various clinical specimens from outpatients and inpatients of the First Affiliated Hospital of Dali University from 2018~2019 were collected and subjected to isolation and culture, bacterial identification, drug sensitivity test and result determination. Results: A total of 267 strains of Streptococcus agalactiae were isolated from our hospital in 2018~2020, and the distribution of departments was mainly concentrated in obstetrics (46.07%) and gynecology (31.46%); specimens were mainly from secretions (84.27%), followed by middle urine (7.49%) and sputum (3.00%); patients aged 18~60 years accounted for the largest proportion (86.89%); infections 87.27% of patients with Streptococcus agalactiae were female; among 267 strains of Streptococcus agalactiae, resistance to oxazolidinones linezolid, tigecycline, and amoxicillin was 0%, cefamandole resistance was 91.32%, levofloxacin resistance was 47.92%, tetracycline resistance was 76.81%, moxifloxacin resistance was 47.92%, furantoin resistance was 7.92%, ciprofloxacin resistance was 20%, azithromycin resistance was 28.30%, and both penicillin and vancomycin resistance was 0.38%. Conclusion: A total of 267 strains of Streptococcus agalactiae were detected in our hospital in 2018~2020, mainly isolated from secretion specimens, and the susceptible population was mainly women aged 18~60 years, especially women of childbearing age were predominant. By analyzing the data, it was found that cefamandole and tetracycline are not recommended for the treatment of patients infected by Streptococcus agalactiae; tigecycline, oxazolidinone linezolid and amoxicillin are recommended as first-line drugs for patients with Streptococcus agalactiae infection.
%K 无乳链球菌，耐药<br>S. agalactiae
%K Drug Resistance
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=49973