%0 Journal Article %T SARS-COV-2 Induce Pulmonary Injury from Basic to Clinical Research %A Jinguo Zhu %J World Journal of Cardiovascular Diseases %P 168-190 %@ 2164-5337 %D 2022 %I Scientific Research Publishing %R 10.4236/wjcd.2022.123018 %X The SARS-CoV-2 has infected over 194,909,000 cases and over 4,170,000 deaths in the world before the end of July 2021. The virus attacks human alveoli and induces severe lung injury (COVID-19 disease) and spreads rapidly. The mechanisms of COVID-19 disease are unclear. To better understand this disease, This review analyzes the SARS-CoV-2 biological characteristics, insights the effect of alveolar epithelium and its adjacent microvascular endothelium, investigates human host cells immune response and immunothrombosis. Explains clinical manifestations of COVID-19 associated lung injury. It may be helpful for development management strategies for COVID-19 associated pulmonary damage. %K COVID-19 %K SARS-CoV-2 %K Pulmonary Injury %K Clinical Manifestation %K Treatment Strategies %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=116331