%0 Journal Article
%T Creutzfeldt Jacob¡¯s Disease: A Senegalese Observation
%A Ahmadou Bamba Mbodji
%A Alassane Mamadou Diop
%A Momo Banda Ndiaye
%A Serigne Saliou Mbacke
%A Khalifa Ababacar Mbaye
%A Rokhaya Diagne
%A Ibrahima Niang
%A Ndiaga Matar Gaye
%A Maouly Fall
%A Adjaratou Sow
%A Anna Basse
%A Lala Bouna Seck
%A Moustapha Ndiaye
%A Amadou Gallo Diop
%J Neuroscience & Medicine
%P 43-48
%@ 2158-2947
%D 2022
%I Scientific Research Publishing
%R 10.4236/nm.2022.131003
%X Creuzfelt-Jakob Disease is a rare and progressive neurodegenerative disease that results in fatal, transmissible, subacute, spongiform encephalopathy characterized by rapidly progressive dementia and movement disorder. We present a 62-year-old male with no medical history who was admitted to our hospital because of gait and balance disturbance, language impairment and progressive motor deficit of the four limbs. A neurological examination found frontal lobe syndrome signs, myoclonic movements, pyramidal and extra-pyramidal signs. Brain Magnetic Resonance Imaging detected high intensity areas in the basal ganglia. EEG showed generalized triphasic sharp-wave complexes. A Cerebro Spinal Fluid examination found protein 14-3-3. Death occurred six months after onset. This is the first known case of Creuzfelt-Jakob Disease documented in Senegal.
%K Creutzfeldt-Jakob Disease
%K Protein 14-3-3
%K Prion Disease
%K Rapidly Progressive Dementia
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=115685