%0 Journal Article
%T Factors Associated with Splenomegaly amongst Patients with Sickle Cell Disease in Cameroon
%A Eposse Ekoube Charlotte
%A Alima Yanda Anastasia Nicole
%A Djike Puepi Yolande
%A Cheping Kouokam Line
%A Mandeng Ma Linwa Edgar
%A Fran£¿oise Ngnedjou Nwabufor Foute
%A Mbono Ritha
%A Epee Patricia
%A Wete Estelle
%A Hassanatou Iyawa
%A Koki Ndombo Paul Olivier
%J Open Journal of Pediatrics
%P 33-46
%@ 2160-8776
%D 2022
%I Scientific Research Publishing
%R 10.4236/ojped.2022.121005
%X <strong>Introduction: </strong><span><span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">Sickle cell disease is the most common hemoglobinopathy in the world.
Sickle cells are quickly fixed and destroyed by the elements of the
reticuloendothelial system mainly in the spleen. It leads to a palpable
increase in the volume of </span><span><span style=\"font-family:Verdana;\">the spleen called
splenomegaly. Splenomegaly is the cause of multiple complications that are
relatively frequent and potentially serious in sickle cell disease, such as
splenic sequestration seizures, spleen rupture, hypersplenism and splenic
abscesses. We aimed at determining the prevalence of splenomegaly and to study
the associated factors in patients with sickle cell disease. </span><b><span style=\"font-family:Verdana;\">Materials</span></b></span><b><span style=\"font-family:Verdana;\"> and Methods: </span></b><span style=\"font-family:Verdana;\">This was an analytical cross-sectional study, conducted from 1
January to 30 April 2019, at the Mother and Child Center of the Chantal BIYA
Foundation. Patients were grouped into two groups: patients with splenomegaly
(PS1) and patients without splenomegaly (PS0). As soon as we obtained the
informed consent of the parents, we examined the children and recorded
socio-demographic data, disease history and follow-up, documented
complications, and clinical findings; then we performed the Rapid Malaria
Diagnostic Test. The statistical analyzes were carried out using SPSS20
(Statistical Package for Social Sciences) and Microsoft Excel 2010 software. </span><b><span style=\"font-family:Verdana;\">Results: </span></b><span style=\"font-family:Verdana;\">We examined 403 children with sickle cell disease and 142 had splenomegaly
(35%). Almost all of the study population</span></span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">s</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\"> were
homo</span><span style=\"font-family:Verdana;\">zygous SS. The Hackett 2 stage of
splenomegaly was the most frequent</span><span style=\"font-family:Verdana;\"> (56.7%). The most common physical sign
among PS1 was the presence of abdominal scarring (50.7% vs. 19.4%). PS1 had
significantly lower levels of Hb (6.94 ¡À 1.67 vs 7.62 ¡À 1.43 p = 0.003) and
platelets (297.45 ¡À 146.25 vs 398.70 ¡À 163.73 p &lt; 0.001) than patients
without splenomegaly (PS0). However, the percentages of HbF (21.78 ¡À 10.48 vs
15.66
%K Sickle Cell Disease
%K Splenomegaly
%K Thalassemia
%K Malaria
%K Associated Factors
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=115175