%0 Journal Article
%T Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by <i>in Silico</i>, <i>in Vitro</i> and <i>in Vivo</i> Methods
%A Baktygul Ernazarova
%A Taitokur Zhusubaliev
%A Zarylkan Asilbek kyzy
%A Aida Bakirova
%A Gulsara Zhusupbaeva
%A Orozby Akparalieva
%A Zhypargul Abdullaeva
%A Nasibakhon Razykova
%A Asilkan Dzhumanazarova
%A Galina Apryshko
%A Alina Orozmatova
%J Journal of Agricultural Chemistry and Environment
%P 15-23
%@ 2325-744X
%D 2022
%I Scientific Research Publishing
%R 10.4236/jacen.2022.111002
%X Computer analysis of N-(<em>¦Â</em>-D-galactopyranosyl)-thiosemicarbazide compounds by <em>in silico </em>method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza), antitumor (antineoplastic) 9 &gt; Pa &gt; 0.5 and with a low probability of cytotoxic/cytostatic (cytostatic/cytotoxic) activities. An experimental study by<em> in vitro</em> and<em> in vivo</em> methods allowed us to conclude that studied new synthetic compound N-(<em>¦Â</em>-D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effects.
%K Biological Activity
%K Synthesis
%K Urea
%K Carbohydrate
%K Compounds
%K Hyperurcemia
%K Ototoxicity
%K Testing
%K Toxicity
%K Anti Tuberculosis
%K Antitumor
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=114738