%0 Journal Article
%T 非小细胞肺癌驱动基因的研究<br>Study on Driver Genes of Non-Small Cell Lung Cancer
%A 曹涤非
%A 薛佳莹
%A 黄国庆
%J Hans Journal of Biomedicine
%P 9-17
%@ 2161-8984
%D 2022
%I Hans Publishing
%R 10.12677/HJBM.2022.121002
%X 肺癌是我国的高发癌症，非小细胞肺癌占肺癌的80%以上。利用基因组测序技术针对非小细胞肺癌的研究发现，一些基因在非小细胞肺癌中频繁发生突变，这些突变调控细胞的生长与分化，是癌症发生的驱动基因。目前，针对非小细胞肺癌的驱动基因临床上已有部分靶点药物，但疗效不显著，靶点药物还有待开发。因此，本研究将对非小细胞肺癌中的驱动基因的作用机制和临床治疗进行综述，以期为靶点药物的开发提供基础。<br />
Lung cancer is a high-incidence cancer in China, and non-small cell lung cancer accounts for more than 80% of lung cancers. Research on non-small cell lung cancer using genome sequencing technology has found that some genes frequently undergo mutations in it. These mutations regulate cell growth and differentiation, which are driving genes for cancer. At present, there are some clinically targeted drugs of non-small cell lung cancer, but effect is not significant, so the target drugs have to be developed. Therefore, this study will review the mechanism and clinical treatment of driver genes in non-small cell lung cancer, in order to provide a basis for the development of target drugs.
%K 肺癌，非小细胞肺癌，驱动基因，突变<br>Lung Cancer
%K NSCLC
%K Driver-Gene
%K Mutation
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=47602