%0 Journal Article
%T 间充质干细胞外泌体在糖尿病肾病治疗中的研究进展<br>The Research Progress of Mesenchymal Stem Cells’ Exosomes in the Treatment of Diabetic Nephropathy
%A 张芷薇
%J Advances in Clinical Medicine
%P 5905-5910
%@ 2161-8720
%D 2021
%I Hans Publishing
%R 10.12677/ACM.2021.1112875
%X 糖尿病肾病(Diabetic Nephropathy, DN)易进展为终末期肾病，目前对其的治疗主要以降血糖、对症支持治疗及肾脏替代治疗等为主，缺乏有效的干预疾病进展的手段。间充质干细胞(mesenchymal stem cells, MSCs)因其具有免疫抑制作用和易再生的特性，被视为免疫、炎症性疾病的新治疗剂，其对糖尿病肾病的有效治疗得到许多实验和临床研究证明，而大多数MSCs介导的有益作用归因于源自MSCs的外泌体(mesenchymal stem cells’ exosomes, MSC-exos)的作用。我们综述了MSC-exos在治疗DN的研究进展。<br />
Diabetic nephropathy (DN) is easy to progress to end-stage renal disease. At present, the treatment of DN is mainly based on controlling blood glucose, symptomatic and supportive treatment and renal replacement therapy. There is a lack of effective means to intervene the progression of DN. Mesenchymal stem cells (MSCs) are regarded as new therapeutic agents for immune and inflammatory diseases because of their immunosuppressive effects and regenerative properties, and their effective treatment for DN has been demonstrated by many experimental and clinical studies, while most MSCs mediated beneficial effects are attributed to the effects of exosomes (MSC-exos) derived from MSCs. We review the research progress of MSC-exos in the treatment of DN.
%K 糖尿病肾病，间充质干细胞，外泌体<br>Diabetic Nephropathy
%K Mesenchymal Stem Cells
%K Exosomes
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=47417