%0 Journal Article
%T 高迁移率族蛋白B1在呼吸系统疾病中的研究进展<br>Research Progress of High-Mobility Group Box Protein B1 in Respiratory Diseases
%A 邵润玉
%A 张彩莲
%A 郭晋兰
%A 李欣
%A 门凯
%J Advances in Clinical Medicine
%P 4976-4982
%@ 2161-8720
%D 2021
%I Hans Publishing
%R 10.12677/ACM.2021.1111731
%X 促炎因子高迁移率族蛋白盒(High Mobility Group Box Protein)是一种非组蛋白且普遍存在的染色体蛋白，富含构成高迁移率族蛋白家族一部分的活性染色质，由人类hmgb1基因(13q12)编码，特别是高迁移率族蛋白具有特定的基序，即脱氧核糖核酸结合域。高迁徙率族蛋白家族有四个成员(HMGB1-4)，其中HMGB1蛋白(也称为HMG1、HMG-1、HMG 1、amphoterin、p30)是整个HMG家族蛋白中表达频率最高的。本文就HMGB1在呼吸系统疾病中的作用、应用和潜在的诊断应用作一综述，以期为上述疾病诊断和治疗提供新思路。<br />
The proinflammatory factor high-mobility group box protein (HMGB) is a non-histone and ubiquitous chro-mosomal protein found enriched in active chromatin forming part of the high mobility group family of proteins and is encoded by the HMGB1 gene (13q12) in human. In particular HMGBs have specific motifs that are DNA-binding domains. The HMGBs are composed of four categories (HMGB1-4). HMGB1 (also known as HMG1, HMG-1, HMG 1, amphoterin, p30) is the most frequently expressed of the entire HMG family proteins. This review aim is to analyse advances on HMGB1 role, employment and potential diagnostic application in disease of respiratory system. It is expected to provide new ideas for the diagnosis and treatment of these diseases.
%K HMGB1，哮喘，肺纤维化，慢阻肺，肺炎，肺癌<br>HMGB1
%K Asthma
%K Pulmonary Fibrosis
%K COPD
%K Pneumonia
%K Lung Cancer
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=46385