%0 Journal Article
%T 外泌体在组织工程中的研究进展<br>The Research Progress of Exosomes in Tissue Engineering
%A 刘纪娜
%A 梁云云
%A 杨宇民
%A 赵亚红
%J Bioprocess
%P 85-91
%@ 2164-5582
%D 2021
%I Hans Publishing
%R 10.12677/BP.2021.114010
%X <div style=\"text-align:justify;\">
	<span style=\"font-size:14px;\">从细胞释放的外泌体，以膜包围的细胞外囊泡的形式，传递蛋白质和核酸，在细胞间通讯中起着至关重要的作用。外泌体的治疗潜力几乎是无限的，特别是从各种组织细胞中收获的外泌体不会引起宿主自身免疫反应，使得外泌体在组织工程移植手术和移植物抗宿主疾病的治疗中，提供了希望。然而，在移植后，维持外泌体随时间的保留和稳定性是外泌体应用的主要挑战。将基于外泌体的递送与多种组织工程材料相结合，不仅可以将外泌体有效负载，而且能有效的将外泌体持久保留在组织缺损部位，满足外泌体高效的停留和持续释放，并为组织再生提供理想的微环境。开发外泌体与各种形式的组织工程支架为组合的无细胞系统，有望用作生物实体，潜在地促进新的生物功能支架的开发，为组织再生提供了有希望的策略。<br />
Exosomes are extracellular vesicles
surrounded by membrane released by nearly all cell types. It has been
demonstrated that exosomes transfer proteins and nucleic acids via their cargo
and play a critical role in intracellular communication. Exosomes are almost
universal and exosomes harvested from all tissues and cells do not induce
autoimmune responses, offering a promising therapeutic option in tissue
engineering transplant surgery and the treatment of graft-versus-host disease.
However, the main challenge for exosomes application is the maintenance of
efficiency and stability of exosomes after transplantation in vivo</span><span style=\"font-size:14px;\">. The combination of exosomes delivery and tissue
engineering based materials can not only carry exosomes, but also effectively
retain exosomes in the defect sites of tissue and release for a long time,
which provide an ideal microenvironment for tissue regeneration. The
development of cell-free systems combining exosomes with various forms of
tissue-engineered scaffolds is expected to be used as biological entities,
promoting the development of new biofunctional scaffolds and providing
promising strategies for tissue regeneration.</span><span style=\"font-size:14px;\"></span> 
</div>
%K 外泌体，组织工程，生物材料<br> Exosomes
%K Tissue Engineering
%K Biomaterials
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=45959