%0 Journal Article
%T 帕金森病的致病因素及治疗<br> Pathogenic Factors and Treatment of Parkinson’s Disease
%A 姜育辉
%A 刘晓宇
%A 周胜鸾
%A 杨宇民
%J Bioprocess
%P 67-75
%@ 2164-5582
%D 2021
%I Hans Publishing
%R 10.12677/BP.2021.114008
%X <div style=\"text-align:justify;\">
	<span style=\"font-size:14px;\">帕金森病(Parkinson’s disease, PD)，是继阿兹海默症之后的第二大神经退行性疾病。据统计，全球超过一半的帕金森病患者都是中国人，帕金森病已经成为</span><span style=\"font-size:14px;\">继心血管疾病、肿瘤之后的我国中老年人的第三杀手。根据起源，该病主要分遗传性和特发性两种。帕金森病患者神经病理学特征常表现为大脑黑质区域多巴胺能神经元的缺失和特定神经元内</span><span style=\"font-size:14px;\">α-突触核蛋白(α-syn)的沉积。帕金森病主要表现为一系列的运动功能障碍，如震颤、僵直、姿势和步态异常等。帕金森病的发病机理涉及多种因素，如线粒体功能障碍、氧化应激、神经炎症等，现在仍然未有定论，因此也未有药物可以完全的抑制疾病的进程和治愈疾病，现多用左旋多巴和多巴胺激动剂治疗PD，也会辅助一些物理康复治疗。所以，如何在多致病因素的情况下寻找到治疗的有效方法是未来研究中的大挑战，同时也是研究的热点。<br />
Parkinson’s disease (PD) is the
second largest neurodegenerative disease after Alzheimer’s disease. According
to statistics, more than half of the patients with Parkinson’s disease in the
world are Chinese. Parkinson’s disease has become the third killer of
middle-aged and elderly people in China after cardiovascular diseases and
tumors. According to the origin, the disease is mainly divided into hereditary
and idiopathic. The neuropathological characteristics of patients with
Parkinson’s disease are often manifested in the absence of dopaminergic neurons
in the substantia nigra and α-Synuclein deposition in specific neurons. Parkinson’s
disease is mainly characterized by a series of motor dysfunction, such as
tremor, stiffness, abnormal posture and gait and so on. The pathogenesis of Parkinson’s disease involves many factors, such as
mitochondrial dysfunction, oxidative stress, neuroinflammation, etc. There
is still no final conclusion. Therefore, there is no drug that can completely
inhibit the process of the disease and cure the disease. Now, levodopa and
dopamine agonists are used to treat PD, and some physical rehabilitation
treatments will also be assisted. Therefore, how to find an effective treatment
in the case of multiple pathogenic factors is not only a great challenge in
future research, but also a research hotspot.</span> 
</div>
%K 帕金森病，α-突触核蛋白，运动功能障碍，康复治疗<br> Parkinson’s Disease
%K α-Synuclein
%K Motor Dysfunction
%K Rehabilitation Therapy
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=45874