%0 Journal Article
%T TCCA/NCS-Promoted Cascade Cyclization of <i>¦Â</i>, <i>¦Ã</i>-Unsaturated Compounds: Synthesis of Isoxazolines and Pyrazolines
%A Khidir Tajelseir Othman
%A Nibras Ahmed Elaas
%J International Journal of Organic Chemistry
%P 187-198
%@ 2161-4695
%D 2021
%I Scientific Research Publishing
%R 10.4236/ijoc.2021.114013
%X 2-Isoxazolines
and 2-pyrazolines have been derived from oxime and hydrazone derivatives
reacted with <i><i><span style=\"font-family:Verdana;\">N</span></i></i><span style=\"font-family:Verdana;\">-chlorosuccinimide (NCS) and trichloroisocyanuric
acid (TCCA). Cyclization strategy is developed for the reaction of <i></i></span><i><i><span style=\"font-family:Verdana;\">¦Â</span></i></i><span><span style=\"font-family:Verdana;\">, <i></i></span><i><i><span style=\"font-family:Verdana;\">¦Ã</span></i></i></span><span style=\"font-family:Verdana;\">-unsaturated
hydrazones with the TCCA to drive 2-pyrazolines and the reaction of <i></i></span><i><i><span style=\"font-family:Verdana;\">¦Â</span></i></i><span><span style=\"font-family:Verdana;\">, <i></i></span><i><i><span style=\"font-family:Verdana;\">¦Ã</span></i></i></span><span style=\"font-family:Verdana;\">-unsaturated
oximes with NCS to derive 2-isoxalzolines. Structures of all new 2-isoxazolines
and 2-pyrazolines have been elucidated by microanalyses, <sup></sup></span><sup><span style=\"font-family:Verdana;\">1</span></sup><span style=\"font-family:Verdana;\">H, <sup></sup></span><sup><span style=\"font-family:Verdana;\">13</span></sup><span style=\"font-family:Verdana;\">C NMR and Mass spectroscopies.</span>
%K 2-Isoxazolines
%K 2-Pyrazolines
%K NCS
%K TCCA
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=113249