%0 Journal Article
%T Anti-Melanogenesis Effect of Daniellic Acid Isolated from <i>Daniellia oliveri</i> (Rolfe) Hutch. & Dalziel (Leguminosae) Oleoresin of Burkina Faso
%A Aminata P. Nacoulma
%A Moussa Compaor¨¦
%A Naamwin-so-Bawfu Romaric Meda
%A Laurent Pottier
%A V¨¦ronique Megalizzi
%A Issa Some
%A Martin Kiendrebeogo
%J Open Journal of Medicinal Chemistry
%P 41-57
%@ 2164-313X
%D 2021
%I Scientific Research Publishing
%R 10.4236/ojmc.2021.114004
%X Over the past years, natural products have been used as useful candidates
for prevention and treatment of skin disorders such as skin darkening. In this
current research, <i><span style=\"font-family:Verdana;\">Daniellia oliveri</span></i><span style=\"font-family:Verdana;\"> which was a potential source of
cosmeceutical agent was selected to investigate its active components.
Daniellic acid isolated from the oleoresin was characterized by using data from </span><sup><span style=\"font-family:Verdana;\">1</span></sup><span style=\"font-family:Verdana;\">H-NMR, </span><sup><span style=\"font-family:Verdana;\">13</span></sup><span style=\"font-family:Verdana;\">C-NMR, HSQC, IR, and online chemo-informatic
analysis. The daniellic acid antioxidant, anti-proliferative, and tyrosinase
inhibition capabilities were evaluated. This compound possessed an anti-DPPH
and iron (III) reducing effect compared to quercetin. It was able to inhibit 9
tumor cells with IC</span><sub><span style=\"font-family:Verdana;\">50</span></sub><span style=\"font-family:Verdana;\"> going from 0.03 mM (U373) to 0.14 mM
(Malme-3M). Interestingly daniellic acid inhibit</span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">s</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\"> tyrosinase activity with 1.20 mM as IC</span><sub><span style=\"font-family:Verdana;\">50</span></sub><span style=\"font-family:Verdana;\">. The tyrosinase inhibition
mechanism was noncompetitive mixed-type with un-significant effect on cell
melanogenesis. Daniellic acids induced a half-reduction of melanin production
in B16F10 cell in IBMX stimulation (p</span></span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">&lt;</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">0.05).
The same observation was effective in Malme-3M melanin production with a
significant daniellic acid action than kojic acid (p</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">&lt;</span></span></span><span><span><span style=\"font-family:;\" \"=\"\">
%K &lt
%K i&gt
%K Daniellia oliveri&lt
%K /i&gt
%K Daniellic Acid
%K Tyrosinase
%K Melanogenesis
%K Cytotoxicity
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=112897