%0 Journal Article %T Total Peritoneal Gutter Removal versus Random Peritoneal Biopsy in Cases of Ovarian Cancer %A Ahmed Abdel-Azeem Essmat %A Mahmoud El-Sayed Meleis %A Helmy Abdel-Sattar Rady %A Inass Ibrahim Ahmed Zaki %A Ahmed Shaaban Ali Ragab Khattab %J Open Journal of Obstetrics and Gynecology %P 1342-1350 %@ 2160-8806 %D 2021 %I Scientific Research Publishing %R 10.4236/ojog.2021.1110125 %X Introduction: Ovarian cancer is the fourth most prevalent cancer among women and the seventh most common cancer overall. Every year, an estimated 200,000 cases and 125,000 deaths related to ovarian cancer are reported around the world. It is most common in high-resource countries, with an incidence rate of 9.3 per 100,000 women. Ovarian cancer is detected at an advanced stage in about 70% of instances, and only 30% of women with such cancers live for more than 5 years. Although only around 20% of ovarian cancers are limited to the ovaries at diagnosis, patients with localized disease have a 5-year survival rate of more than 90%. Peritonectomy is a crucial part of the surgical treatment for ovarian cancer. Visual inspection and palpation are not reliable methods for determining the extent of tumour involvement. The majority of gynecologic oncologists are suspicious about the benefits of a full peritonectomy, concerned about the benefits and hazards. They believe that the tumor¡¯s fundamental biology, not surgical aggressiveness, dictates the tumor¡¯s resectability. The aim of this work was primarily to compare the differences between total peritoneal gutter removal and random peritoneal biopsy in cases of early ovarian cancer. A secondary aim of this work is to show ability of total peritoneal gutter removal in relation to that of random peritoneal biopsy to detect positivity of metastasis in the histopathological specimens. Patients and Methods: This prospective cohort study was conducted on 130 patients with early ovarian cancer in El-Shatby hospital, Faculty of Medicine, Alexandria University. For each patient, we took random and total peritoneal biopsy and compared between them regarding technique, timing, post-operative complications, and histopathological results. Inclusion criteria: all age group, suspected ovarian cancer using IOTA score, absence of nodules in the peritoneal gutter using CT and any case that needs staging laparotomy for ovarian cancer. Exclusion criteria: