%0 Journal Article
%T Efficacy and Safety of Misoprostol Vaginal Insert to Induce Labor beyond 40 + 0 Weeks of Gestation
%A Catharina Krause
%A Christian Rudlowski
%A Melanie Erices-Leclercq
%A David Tenckhoff
%A Sabine Lubig
%J Open Journal of Obstetrics and Gynecology
%P 1333-1341
%@ 2160-8806
%D 2021
%I Scientific Research Publishing
%R 10.4236/ojog.2021.1110124
%X <strong>Objective:</strong><span><span style=\"font-family:Verdana;\"> Misoprostol vaginal insert (MVI) is proven to
induce labor by a </span><span style=\"font-family:Verdana;\">continuously release of PGE1.
Previous reports showed that MVI reduced</span><span style=\"font-family:Verdana;\"> induction to delivery time as
well as active labor time but it also increased uterine tachysystole. Here we
attempted to clarify whether MVI is safe and </span><span style=\"font-family:Verdana;\">efficient
for women with pregnancies &gt;40 weeks in a single institute.</span> <b><span style=\"font-family:Verdana;\">Methods: </span></b><span style=\"font-family:Verdana;\">This study was performed in Lutheran Hospital Bergisch Gladbach, Germany
2014-2019. A total of 304 women between 40 + 0 to 42 + 0 weeks underwent labor
induction with MVI. Outcomes were</span></span><span style=\"font-family:Verdana;\">:</span><span><span style=\"font-family:Verdana;\"> 1) maternal: time from
insertion </span><span style=\"font-family:Verdana;\">to delivery, interventions, mode
of delivery, and uterine tachysystole, 2)</span><span style=\"font-family:Verdana;\"> neo</span></span><span style=\"font-family:Verdana;\">-</span><span><span style=\"font-family:Verdana;\">natal:
cord blood pH, APGAR scores, and admission to a neonatal clinic. This </span><span style=\"font-family:Verdana;\">study ended unexpectedly due to the withdrawal of
MVI (Misodel<span style=\"white-space:nowrap;\">&lt;sup&gt;TM&lt;/sup&gt;</span>) in</span><span style=\"font-family:Verdana;\"> September 2019. </span><b><span style=\"font-family:Verdana;\">Results: </span></b><span style=\"font-family:Verdana;\">75.7% (n = 230) of women
gave birth within 24 hours after MVI placement. 72.2% (n = 140) nulliparous
women and 81.8% (n = 90) </span><span style=\"font-family:Verdana;\">parous women
delivered within 24 hours. In two cases emergency CS was</span><span style=\"font-family:Verdana;\"> required. 67.8%
(n = 206) of women delivered vaginal. 2.3% (n = 7) of cord pH levels were below
7.10. 3.3% (n = 10) of newborns were transmitted to a neonatal clinic. </span><b><span style=\"font-family:Verdana;\">Conclusion: </span></b><span style=\"font-family:Verdana;\">MVI is an efficient method to induce labor for </span><span style=\"font-family:Verdana;\">pregnant women beyond 40 + 0 weeks. However, considering various</span><span style=\"font-family:Verdana;\"> compli</span><span style=\"font-family:Verdana;\">cations observed (uterine tachysystole
and fetal distress leading to a high</span><span
%K Misoprostol Vaginal Insert
%K Induction of Labor
%K Caesarean Section
%K Vaginal Delivery
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=112472