%0 Journal Article
%T Transmission Based Conditional Logistic Model for Testing Main and Interaction Effects
%A Caixia Li
%A Peixing Li
%J Open Journal of Statistics
%P 713-719
%@ 2161-7198
%D 2021
%I Scientific Research Publishing
%R 10.4236/ojs.2021.115042
%X Transmission disequilibrium
test (TDT) is a popular family based genetic association method. Under
multiplicative assumption, a conditional logistic regression for matched pair, affected
offspring with allele transmitted from parents and pseudo-offspring (control)
with allele non-transmitted from parents, was built to detect the <span style=\"font-family:Verdana;\">main </span><span style=\"font-family:Verdana;\">effects of genes and gene-covariate
interaction</span><span style=\"font-family:Verdana;\">s</span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">. When
there exist genotype uncertainties, expectation-maximization (EM) algorithm was
adopted to estimate the coefficients. The transmission model was applied to
detect the association between M235T polymorphism in AGT gene and essential
hypertension (ESH). Most of parents are not available in the 126 families from
HongKong Chinese population. The results </span><span style=\"font-family:Verdana;\">showed
M235T is associat</span></span><span style=\"font-family:Verdana;\">ed</span><span style=\"font-family:Verdana;\"> with hypertension and there is interaction between
M235T and the case¡¯s sex. The allele T is higher risk for male than female</span><span style=\"font-family:Verdana;\">.</span>
%K Transmission Disequilibrium Test
%K Gene-Covariate Interaction
%K Conditional Logistic Model
%K Expectation-Maximization Algorithm
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=112377