%0 Journal Article
%T Risk Factors and Outcome of Overt Stroke in Sickle Cell Patients Admitted in Two Reference Hospitals in Yaounde and Douala
%A Eposse Ekoube Charlotte
%A Alima Yanda Anastasie Nicole
%A Ekotto Karen Ingrid
%A Mandeng Ma Linwa Edgar
%A Ngo Linwa Esther Eleonore
%A Mbono Ritha
%A Djike Puepi Yolande
%A Epee Patricia
%A Dora Mbanya
%A Mbassi Awa
%J Open Journal of Pediatrics
%P 503-516
%@ 2160-8776
%D 2021
%I Scientific Research Publishing
%R 10.4236/ojped.2021.113047
%X Background: Worldwide, the prevalence of sickle cell disease (SCD) as of 2016 was
estimated at 2%; that is 300,000
births annually. This study was focused on homozygous sickle cell disease which
leads to several complications notably hemolytic crises, aplastic crises and
vaso-occlusive crises like stroke. Sickle cell disease is the most common cause
of childhood stroke. Stroke occurs in 17% - 24% of
sickle cell children worldwide. Objectives: To determine the risk factors for overt stroke and outcome at discharge in
sickle cell disease patients admitted in two reference hospitals in Cameroon. Method: This was a case-control study in two reference hospitals in Yaounde and
Douala, carried out over the duration of 4 months, covering a 5-year period
(December 2013 to December 2018). Included in the study, were all homozygous
sickle cell children aged 6 months to 16 years during that period with or
without stroke. A total of 1734 patients fulfilled the inclusion criteria. Out
of these, 49 stroke patients participated and 687 were selected as controls.
Data was collected from the patients¡¯ files and books on a pretested data
collection form, then entered in the software C.S Pro 7.1 before analysis.
Stroke outcome at discharge was assessed using the modified Rankin scale (mRs)
with structured interview. A patient was classified as good outcome if mRs