%0 Journal Article
%T Synthesis and Antibacterial Activities  of New 2-(Benzylthio)pyrimidines and  2-(Benzimidazolylmethylthio)pyrimidines Derivatives
%A Achi Patrick-Armand
%A Coulibali Siomenan
%A Zon Doumade
%A Timotou Ad¨¦yol¨¦
%A Bolou Eric
%A Tour¨¦ Daouda
%A Sissouma Drissa
%A Adjou An¨¦
%J Open Journal of Medicinal Chemistry
%P 27-39
%@ 2164-313X
%D 2021
%I Scientific Research Publishing
%R 10.4236/ojmc.2021.113003
%X A series of 2-<span style=\"font-family:Verdana;\">(</span><span style=\"font-family:Verdana;\">benzylthio</span><span style=\"font-family:Verdana;\">)</span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">pyrimidines (</span><b><span style=\"font-family:Verdana;\">6a-l</span></b><span style=\"font-family:Verdana;\">) and</span></span><span style=\"font-family:Verdana;\"> 2-(benzimidazolylmethylthio</span><span style=\"font-family:Verdana;\">)-</span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">pyrimidines derivatives (</span><b><span style=\"font-family:Verdana;\">6m</span></b><span style=\"font-family:Verdana;\"> and </span><b><span style=\"font-family:Verdana;\">6n</span></b><span style=\"font-family:Verdana;\">) analogues of ethyl 2-(benzylthio)-6-methyl-</span></span><span style=\"font-family:Verdana;\">4-phenyl-1,4-dihydropyrimidine-5-carboxylates
and ethyl 2-(((1H-benzimi</span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">da</span><span style=\"font-family:Verdana;\">zol-</span></span><span style=\"font-family:Verdana;\">2-yl)methyl)thio)-6-methyl-4-phenyl-1,4-dihydropyri</span><span style=\"font-family:Verdana;\">-</span><span style=\"font-family:Verdana;\">midine-5-carboxy</span><span style=\"font-family:Verdana;\">l</span><span style=\"font-family:Verdana;\">ates</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">were prepared and evaluated for antibacterial
activity. These com</span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">pounds were </span><span><span style=\"font-family:Verdana;\">obtained by condensation
of 2-thiopyrimidines (</span><b><span style=\"font-family:Verdana;\">4</span></b><span style=\"font-family:Verdana;\">) with benzyl halides or</span></span><span style=\"font-family:Verdana;\"> 2-</span></span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">(chloromethyl)-</span><i><span style=\"font-family:Verdana;\">1H</span></i><span style=\"font-family:Verdana;\">-benzimidazole (</span><b><span style=\"font-family:Verdana;\">5</span></b><span style=\"font-family:Verdana;\">) in the
presence of a base. All com</span></span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">pounds were characterized by </span><sup><span style=\"font-family:Verdana;\">1</span></sup><span style=\"font-family:Verdana;\">H, </span><sup><span style=\"font-family:Verdana;\">13</span></sup><span style=\"font-family:Verdana;\">C and HRMS spectra.
Out of
%K 2-Thiopyrimidine
%K Benzylthiouracil
%K Benzimidazole
%K Antibacterial Activity
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=112015