%0 Journal Article
%T Comparative Study between the Use of Regular Folic Acid Supplement versus the Use of L-Methyl Folate in Patients with Methyl Tetrahydrofolate Reductase (MTHFR) Gene Mutation with Recurrent Pregnancy Loss
%A Ahmed Essmat
%J Open Journal of Obstetrics and Gynecology
%P 1104-1111
%@ 2160-8806
%D 2021
%I Scientific Research Publishing
%R 10.4236/ojog.2021.119103
%X <strong>Background:</strong><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"> Methylfolate is the active metabolite of folate
that is importa</span></span></span><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">nt for DNA repair, synthetized under the effect of
MTHFR (methyl-tetrahydro-folatereductase) enzyme. Patients with MTHFR gene
mutation have low levels of biologically active methyfolate. Those patients
have high homocysteine levels causing vasculopathy and inadequate feto-maternal
circulation. </span><b><span style=\"font-family:Verdana;\">Aim of the Work:</span></b><span style=\"font-family:Verdana;\"> To predict the potential benefit of use of
methylfolate instead of use of the regular folic acid in patients with MTHFR
gene mutation with history of RPL</span></span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">(recurrent
pregnancy loss). </span><b><span style=\"font-family:Verdana;\">Subjects and Methods:</span></b><span style=\"font-family:Verdana;\"> Study was performed on 100 women.
All women had experienced at least two consecutive miscarriages first trimester
abortion. All patients were positive of </span><span style=\"font-family:Verdana;\">having
MTHFR gene mutation. Patients were divided into two groups in terms of 1st
trimester drug intake. The 1st group recieved a regular folic acid supplement
in a dose of 5</span></span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">mg per day starting from the day of positive preg</span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">nancy test till the end of the first trimester.</span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">The 2nd
group recieved L-methylfolate supplement in a dose of 1000 mcg per day starting
from the day of positive pregnancy test till the end of the first trimester.
Then both groups were compared in terms of abortion rates, pregnancy
continuation rates and the development of other major obstetric complications. </span><b><span style=\"font-family:Verdana;\">Results:</span></b><span style=\"font-family:Verdana;\">
%K MTHFR
%K Recurrent Pregnancy Loss
%K Folic Acid
%K L-Methylfolate
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=111697