%0 Journal Article
%T Is There Any Role for Calcium Ionophore in ICSI Cycles for Cases of Non Obstructive Azoospermia?
%A Mohamed Elmahdy
%A Yasser Oreif
%A Soad Musleh
%A Emadeldin Khalifa
%J Open Journal of Obstetrics and Gynecology
%P 1037-1049
%@ 2160-8806
%D 2021
%I Scientific Research Publishing
%R 10.4236/ojog.2021.118097
%X <strong>Objectives:</strong><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"> Evaluate the effect of artificial oocyte activation (AOA) using calcium
ionophore (A23187) on the rate of fertilization and cleavage of embryos in
surgically retrieved sperm of patients with non-obstructive azoospermia
undergoing intracytoplasmic sperm injection (ICSI).</span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><b><span style=\"font-family:Verdana;\">Study design: </span></b></span></span><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">This study was conducted on 60 infertile couples undergoing ICSI cycles
as a randomized controlled parallel group¡¯s experimental study in a private IVF
center in Egypt from January 2018 to July 2019. ICSI cycles were divided into
two g</span><span style=\"font-family:Verdana;\">roups: Group A: includes 30 ICSI
patients with surgically retrieved sperms of non-obstructive azoospermia
treated with calcium ionophore (A23187). Group C/Control: includes 30 ICSI
patients with surgically retrieved sperms of non-obstructive azoospermia
non-treated with calcium ionophore (A23187)</span><span style=\"font-family:Verdana;\">. </span><b><span style=\"font-family:Verdana;\">Results: </span></b><span style=\"font-family:Verdana;\">There was
no statistical difference between both groups regarding the fertilization rate
(</span><i><span style=\"font-family:Verdana;\">p</span></i><span style=\"font-family:Verdana;\"> = 0.853). There was no statistical difference between them regarding
implantation rate (</span><i><span style=\"font-family:Verdana;\">p</span></i><span style=\"font-family:Verdana;\"> = 0.237). The percentage
of Class A embryos in the ca ionophore group was 81.7%, while it was 82.8% in
the control group. There was insignificant difference between them (</span><i><span style=\"font-family:Verdana;\">p</span></i><span style=\"font-family:Verdana;\"> =
0.782). There was no statistical significant difference between the two groups
regarding the clinical pregnancy rate</span></span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">,</span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"> it was
(56.7%) in the ca ionophore group while it was (53.3%) in the control
%K Fertilization Failure
%K ICSI
%K Azosperemia
%K Ca Ionophore
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=111429