%0 Journal Article
%T Synthesis, Molecular Structure, Anti-Plasmodial, Antimicrobial and Anti-Oxidant Screening of (E)-1-(Phthalazin-1-yl)-1-[(Pyridin-2-yl)Ethylidene]Hydralazine and 1-[2-(1-(pyridine-3- yl)ethylidene)hydrazinyl]phthalazine
%A Angelbert F. Awantu
%A Godfred A. Ayimele
%A Jean Jules K. Bankeu
%A Edouard A. Nantia
%A Patrick V. T. Fokou
%A Fabrice F. Boyom
%A Emmanuel N. Nfor
%A Bruno N. Lenta
%A Silv¨¨re A. Ngouela
%J International Journal of Organic Chemistry
%P 91-105
%@ 2161-4695
%D 2021
%I Scientific Research Publishing
%R 10.4236/ijoc.2021.113008
%X Two new hydralazine hydrochloride-derived Schiff bases</span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">:</span></span><span style=\"font-family:Verdana;\">&nbsp;(E)-1-(Phthalazin-</span><span style=\"font-family:Verdana;\">&nbsp;</span><span style=\"font-family:Verdana;\">1-yl)-1-[(Pyridin-2-yl)Ethylidene]Hydralazine (PPEH), and 1-[2-(1-(pyridine-</span><span style=\"font-family:Verdana;\">&nbsp;</span><span style=\"font-family:Verdana;\">3</span><span style=\"font-family:Verdana;\">-yl)ethylidene)hydrazinyl]phthalazine (PEHP), were synthesized and partially characterized by spectroscopic and crystallographic methods including IR and X-ray. The single-crystal X-ray diffraction (SCXRD) analysis of PEHP indicate</span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">s</span></span><span style=\"font-family:Verdana;\">&nbsp;that the hydralazine moiety of both ligands possess</span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">es</span></span><span style=\"font-family:Verdana;\">&nbsp;the exoc</span><span style=\"font-family:Verdana;\">yclic C=N bond. Both, PPEH and PEHP were tested as antimicrobials and antiparasites. Just PEHP could be considered as slightly antiplasmodial and antibacterial agent. In effect, PPEH showed low antimicrobial activity against one bacterial strain with Minimum Inhibitory Concentration (MIC) value of 250 ¦Ìg/ml while PEHP showed very interesting activity against 18 out of 19 bacterial strains with MIC of 31.25 </span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">-</span></span><span style=\"font-family:Verdana;\">&nbsp;250 ¦Ìg/ml compared to the standard drug, amoxicillin. PPEH and PEHP showed higher reducing activity on ferric ions compared to Vitamin C. On the other hand, both hidrazaline synthetized derivatives show</span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">ed</span></span><span style=\"font-family:Verdana;\">&nbsp;as better reducing agents than Vitamin C on ferric ions, while again, only the PEHP show</span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">ed</span></span><span style=\"font-family:Verdana;\">&nbsp;slightly high inhibition of lipid peroxidation using Vitamin C as standard. Regarding their catalase activity, both compounds show</span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">ed</span></span><span style=\"font-family:Verdana;\">&nbsp;concentration dependent effect, but Vitamin C continued showing a higher
%K Schiff Base
%K Hydralazine Hydrochloride
%K Anti-Plasmodial Activity
%K Antimicrobial Activity
%K Anti-Oxidant Activity
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=111211