%0 Journal Article
%T Primary Immune Deficiencies (PID):  Diagnosis Challenges
%A Indou Deme/ly
%A Awa Kane
%A Mame Sokhna Gueye
%A Ibrahima Diop
%A Mame Tene Ndiaye
%A Abou Ba
%A Idrissa Demba Ba
%A Babacar Niang
%A Aliou Thiongane
%A Yaay Joor Dieng
%A Yaye Fatou Mbodj/Diop
%A Ouafae Achnin
%A Papa Moctar Faye
%A Amadou Lamine Fall
%A Ibrahima Diagne
%A Tandakha Ndiaye Di¨¨ye
%A Ousmane Ndiaye
%J Open Journal of Pediatrics
%P 388-392
%@ 2160-8776
%D 2021
%I Scientific Research Publishing
%R 10.4236/ojped.2021.113035
%X <strong>Background:</strong><span style=\"font-family:Verdana;\"> Primary Immune Deficiencies (PID) are rare,
under-determined </span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">diseases particularly in sub-Saharan Africa. The
diagnosis is often suspected with uncommon clinical signs. Infections are the
main diagnostic circumstances in infants. Confirmation is often difficult
because some additional examinations are unavailable in many of our countries. </span><b><span style=\"font-family:Verdana;\">Aim: </span></b><span style=\"font-family:Verdana;\">Our aim was to share the challenge of diagnosis and treatment in PID. </span><b><span style=\"font-family:Verdana;\">Case
Presentation:</span></b><span style=\"font-family:Verdana;\"> It is about two infants, a boy and a girl, with early several
infections. Both of them presented a hypo-gammaglobulinemia and to the boy, the
immuno-phenotyping lymphocyte showed a decrease</span></span><span style=\"font-family:Verdana;\">d</span><span style=\"font-family:Verdana;\"> level of lymphocytes CD19. We are looking for
genetic confirmation but it is not easy. The treatment of these infants require</span><span style=\"font-family:Verdana;\">s</span><span style=\"font-family:Verdana;\"> a substitution for life
of immunoglobulin w</span><span style=\"font-family:Verdana;\">h</span><span style=\"font-family:Verdana;\">ich </span><span style=\"font-family:Verdana;\">is</span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\"> unavailable in our
countries. </span><b><span style=\"font-family:Verdana;\">Conclusion:</span></b><span style=\"font-family:Verdana;\"> PID are suspected with atypical clinical signs.
Confirmation genetic diagnosis is difficult in low income countries. To improve
the follow up, we need to strengthen clinical-biological collaboration.</span></span>
%K Primary Immune Deficiencies
%K Hypo-Gammaglobulinemia
%K Infants
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=111182