%0 Journal Article
%T Neonatal and Young Infant Sepsis in a Regional Hospital in Ghana
%A Innocent Afeke
%A Misa Hirose
%A Kokou Hefoume Amegan-Aho
%A Christoph Haertel
%A Mareike Becker
%A Ahmed Moustafa
%A Paul Schilf
%A Mohamed Tarek Badr
%A Graceful Lord Mensah
%A Hintermann Kobina Mbroh
%A Jan Rupp
%A Saleh Ibrahim
%J Open Journal of Pediatrics
%P 281-300
%@ 2160-8776
%D 2021
%I Scientific Research Publishing
%R 10.4236/ojped.2021.112027
%X <strong>Background</strong><b><span style=\"font-family:Verdana;\">: </span></b><span style=\"font-family:Verdana;\">Neonatal sepsis is a global health problem that
mainly affects low- and middle-income countries. We have previously shown that
early neonatal mortality is high at the Ho Teaching Hospital (HTH) of Ghana. We
sought to determine the prevalence of neonatal sepsis, sepsis-related
mortality, and bacterial species patterns in neonatal and young infant sepsis
in this hospital.</span><span style=\"font-family:;\" \"=\"\"> </span><b><span style=\"font-family:Verdana;\">Methods</span></b><b><span style=\"font-family:Verdana;\">:</span></b><b><span style=\"font-family:;\" \"=\"\"> </span></b><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">A hospital-based study was conducted in the
hospital¡¯s neonatal intensive care unit (NICU) from March to June 2018. Blood
samples from 96 babies clinically diagnosed with or at risk of sepsis were
cultured using the BACTEC 9050<span style=\"white-space:nowrap;\">&lt;sup&gt;&amp;reg;&lt;/sup&gt;&nbsp;</span>machine. Clinical data including gravida,
parity and antibiotic medication before delivery of mother and delivery type,
gestation, birth weight and antibiotic medication status were collected for
analysis. MALDI-TOF MS identified bacterial isolates, and their identities were
confirmed via </span><i><span style=\"font-family:Verdana;\">tuf</span></i><span style=\"font-family:Verdana;\"> gene sequence typing. The data were analyzed using
GraphPad Prism 8.0.2.</span></span><span style=\"font-family:;\" \"=\"\"> </span><b><span style=\"font-family:Verdana;\">Results</span></b><b><span style=\"font-family:Verdana;\">: </span></b><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">Blood cultures were positive in 28 of the babies,
with 14 and 12 representing early-onset and late-onset neonatal sepsis,
respectively, and two cases of unknown sepsis type. Of the bacterial species
that caused sepsis in the babies, coagulase-negative staphylococcus (CoNS) was
the most prevalent isolate in 22 cases, followed by </span><i><span style=\"font-family:Verdana;\">Klebsiella pneumoniae </span></i><span style=\"font-family:Verdana;\">in </span><span style=\"font-family:Verdana;\">two and </span><i><span style=\"font-family:Verdana;\">Staphylococcus aureus</span></i><span style=\"font-family:Verdana;\">, </span><i><span style=\"font-family:Verdana;\">Streptococcus agalactiae</span></i><span style=\"font-family:Verdana;\">, the </span><i><span
%K Neonatal Sepsis
%K Neonatal Mortality
%K Healthcare-Associated Infections
%K Neonatal Intensive Care Unit
%K Ho Teaching Hospital of Ghana
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=110004