%0 Journal Article
%T Potential of Natural Killer Cell Enriched Conditioned Media for Skin Care and Anti-Aging
%A Dong Soo Kim
%A Dong Ju Kim
%A Hyun Pyo Kim
%A Sung Hwan Hwang
%A Jung Hwa Kang
%J Journal of Cosmetics, Dermatological Sciences and Applications
%P 123-139
%@ 2161-4512
%D 2021
%I Scientific Research Publishing
%R 10.4236/jcdsa.2021.112013
%X Natural killer (NK) cell is a type of immune cell and is known to be particularly responsible for innate immunity such as anti-cancer immunity, defense mechanisms against infections, and secretion of various cytokines and chemokines for increasing recruitment of other immune cells. In this study, we investigated the potentials of NK-enriched lymphocytes (NKEL) conditioned media (CM) on skin care for cosmeceutical compositions. Various cytokines of NKEL CM can improve wound healing through epithelial-mesenchymal transition (EMT) by increasing KLKs (kallikreins) and reduce metalloproteinase (MMP)-1 and MMP-2 to inhibit wrinkle formation. Our results suggest that NKEL CM which has various cytokines promotes up-regulation of cell migration and KLKs and down-regulation of MMP-1 and MMP-2 by stimulating HaCaT keratinocytes migration. Therefore, NKEL CM can be used as a cosmetic composition that can play a role in skin regeneration and anti-aging.
%K Natural Killer Cell
%K NKEL
%K Skin Care
%K Wound Healing
%K Anti-Aging
%K KLKs
%K MMPs
%K EMT
%K Conditioned Media
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=109714