%0 Journal Article
%T The Use of Hormonal Contraceptives and Preeclampsia among Ghanaian Pregnant Women
%A Listowell Asare
%A George A. Asare
%A William K. B. A. Owiredu
%A Christian Obikorang
%A Efua Appiah
%A Worlanyo Tashie
%A Leila Seidu
%J Open Journal of Obstetrics and Gynecology
%P 419-433
%@ 2160-8806
%D 2021
%I Scientific Research Publishing
%R 10.4236/ojog.2021.114041
%X Hormonal
contraceptives (HC) are thought to play a role in the pathogenesis of
cardiovascular diseases. The study evaluated the use of HC as a primary </span><span style=\"font-family:Verdana;\">cause of preeclampsia (PE) among Ghanaians. This
study comprised 30</span><span style=\"font-family:Verdana;\"> preec</span><span style=\"font-family:Verdana;\">lamptic women
and 30 healthy normotensive pregnant women with over 20</span><span style=\"font-family:Verdana;\"> weeks of
gestation at the Comboni Hospital, Ghana using a randomized </span><span style=\"font-family:Verdana;\">case-control </span><span style=\"font-family:Verdana;\">study. Blood pressure, weight,
height, socio-demographics, medical and previous obstetric history were taken
and recorded. Blood samples were collected for the estimation of homocysteine
and fasting lipids. Estimated foetal weight (EFW) and infant birthweight (BWT)
were obtained from maternal records. This study was carried out in 2019.</span><b> </b><span style=\"font-family:Verdana;\">80.0%
of women with PE used the hormonal contraceptive ˇ°depot medroxyprogesterone
acetateˇ± (DMPA) prior to pregnancy. The use of DMPA was associated with about
thirty-fold increase in the odds of developing PE (OR = 29.71, p</span></span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">&lt;</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">0.001). Systolic blood pressure (P</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">&lt;</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">0.001), diastolic blood pressure (P</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">&lt;</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">0.001), triglycerides (P</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">=</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">0.024),
LDL-C (P</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">=</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">0.026), and homocysteine
levels (P</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">&lt;</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">0.001) were significantly
elevated in the PE cases than the normal pregnant (NP) women, whilst EFW (P</span><span
%K Preeclampsia
%K Hormonal Contraceptives
%K Depot Medroxyprogesterone Acetate
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=108658