%0 Journal Article
%T Porcine Placenta Extract Reduced Wrinkle Formation by Potentiating Epidermal Hydration
%A Akihiro Aioi
%A Ryuta Muromoto
%A Sho Mogami
%A Megumi Nishikawa
%A Shigeyuki Ogawa
%A Tadashi Matsuda
%J Journal of Cosmetics, Dermatological Sciences and Applications
%P 101-109
%@ 2161-4512
%D 2021
%I Scientific Research Publishing
%R 10.4236/jcdsa.2021.112011
%X <strong>Background:</strong> Placenta extract is used as an alternative medicine especially in Asian countries as it is a rich reservoir of diverse bioactive molecules. The effects of placenta extract on skin conditions have been previously reported, however, the mechanism underlying for reduced wrinkle formation remains unclear. <strong>Objective:</strong> The primary objective of this study was to determine whether the continuous application of porcine placenta extract (PPE) alleviates wrinkle formation in humans and explore the underlying mechanism. <strong>Methods:</strong> Wrinkle formation, skin hydration, and skin elasticity were measured in 15 volunteers at weeks 0 and 6 after continuous application of a gel containing PPE. The production of type I collagen and hyaluronic acid from fibroblasts and keratinocytes, respectively, were measured using ELISA. Expression levels of ceramide synthase 3 (CERS3), filaggrin (FLG), transglutaminase 1 (TGM1), and kallikrein-7 (KLK7) were evaluated by quantitative real-time PCR. <strong>Results:</strong> The wrinkle index was significantly reduced to 72.1% after a 6-week of applying the PPE gel, along with a significant increase in skin hydration to 126.5%. Type I collagen production from fibroblasts was enhanced slightly but significantly following treatment with PPE. PPE accelerated the expression of CERS3 (1.85-fold), FLG (1.35-fold), TGM1 (1.76-fold), and KLK7 (1.62-fold). <strong>Conclusion:</strong> Treatment with PPE alleviates wrinkle formation and simultaneously enhances skin hydration, which is induced via the accelerated expression of moisturizing-related proteins. These findings suggest that PPE is effective for combating dryness-induced wrinkle formation.
%K Porcine Placenta
%K Wrinkle Formation
%K Moisturizing-Related Proteins
%K Keratinocyte Differentiation
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=109666