%0 Journal Article
%T 氨基噻唑合成研究进展<br>Study on the Synthesis of Aminothiazole Derivatives
%A 于丽杰
%A RajendranSatheeshkumar
%A 王文龙
%J Hans Journal of Medicinal Chemistry
%P 14-27
%@ 2331-8295
%D 2021
%I Hans Publishing
%R 10.12677/HJMCe.2021.92003
%X 噻唑类化合物具有广泛的生物活性，其中，氨基噻唑作为重要结构单元在药物和药物化学领域中广泛存在。然而原有的Hantzsch合成法存在许多弊端，研究者对其进行了一系列改进，并发现了一些新的合成方法。本文主要从非均相纳米催化合成氨基噻唑，光催化合成氨基噻唑，未使用催化剂合成氨基噻唑，使用绿色溶剂合成氨基噻唑，熔融法合成氨基噻唑，硫氰酸根参与的氨基噻唑合成，其他等方面阐述近几年氨基噻唑的合成研究进展。<br />
Thiazole compounds have a wide range of biological activities. Among of them, 2-aminothiazoles are one of the most important classes of heterocycles in the field of pharmaceutical and medicinal chemistry such as antifungal, insecticidal, radioprotective, bactericidal, antiviral, and anesthetic ac-tivities. The original Hantzsch synthesis has many disadvantages, and researchers have made a se-ries of improvements. This article mainly describes the progress of the synthesis of aminothiazole in recent years.
%K 噻唑，氨基噻唑，Hantzsch方法<br>Thiazole
%K 2-Aminothiazole
%K Hantzsch Synthesis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=41353