%0 Journal Article
%T Palladium-Catalyzed meta-C每H Functionalization of Masked Aromatic Aldehydes
%J -
%D 2018
%R https://doi.org/10.1021/acscatal.8b01599
%X Palladium-catalyzed meta-C每H functionalization enabled by transient mediators has the potential to extend the utility of directed ortho-C每H functionalization to remote positions. However, there have been no reports of palladium-catalyzed meta-C每H functionalization of aromatic aldehyde derivatives, which are highly versatile intermediates in organic synthesis. Herein, we report the development of a directing group that, in the presence of a norbornene-derived mediator and an appropriate pyridone ligand, allows palladium-catalyzed meta-C每H functionalization of masked aromatic aldehydes. Mechanistic insight regarding the impact of the directing group length on this catalysis is also discussed
%U https://pubs.acs.org/doi/10.1021/acscatal.8b01599