%0 Journal Article
%T Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry
%A Andrii Lozynskyi
%A Anna Kryshchyshyn
%A Olexandra Roman
%A Roman Lesyk
%J -
%D 2018
%R https://doi.org/10.3390/scipharm86020026
%X Abstract This review presents the up to date development of fused thiopyranothiazoles that comprise one of the thiazolidine derivatives classes. Thiazolidine and thiazolidinone-related compounds belong to the widely studied heterocycles from a medicinal chemistry perspective. From the chemical point of view, they are perfect heterodienes to undergo hetero-Diels¨CAlder reaction with a variety of dienophiles, yielding regio- and diastereoselectively thiopyranothiazole scaffolds. The annealing of thiazole and thiopyran cycles in condensed heterosystem is a precondition for the ˇ°centers conservativeˇ± creation of the ligand-target binding complex and can promote a potential selectivity to biotargets. The review covers possible therapeutic applications of thiopyrano[2,3- d]thiazoles, such as anti-inflammatory, antibacterial, anticancer as well as aniparasitic activities. Thus, thiopyrano[2,3- d]thiazoles may be used as powerful tools in the development of biologically active agents and drug-like molecules. View Full-Tex
%K 4-thiazolidinones
%K thiopyrano[2
%K 3-d]thiazoles
%K [4+2]-cycloaddition
%K biological activity
%U https://www.mdpi.com/2218-0532/86/2/26