%0 Journal Article
%T The correlation with prognostic factors of bcl-2 and cathepsin D in invasive ductal carcinomas
%A £¿BRAH£¿M GEL£¿NC£¿K
%J -
%D 2018
%X Introduction: Invasive ductal carcinoma which is cancers of the breast is the most common cancer of the breast in women. In this tumors, early diagnosis and appropriate medical treatment is to influence markedly to life span. For this reason, cancers of the breast is occured intesify at therapy with chemotherapotic agents and hormonal treatment for the purpose of prevention systemic spread and prognosis determination of works in the last years. Just reliable determinatives are necessary, because of not to be adequate to orientate treatment and prognosis only class£¿c parameters. For this reason, it was evaluated the correlation with each other and other prognostic factors of bcl-2 and cathepsin D in invasive ductal carcinomas of the breast in the present study. Materials and methods: In the present study. it was included 50 cases diagnosed with invasive ductal carcinoma and examined mastectomy and axillary dissection material. Slides stained with estrogen, progesterone and c-erbB-2 were reviewed again and done scoring separately for each slide.Also in the present study it was stained bcl-2 and cathepsin D expression in 50 invasive ductal carcinomas by imm¨¹nhistochemistry, and evaluated the correlation with other prognostic factors and each other. Results: A strong positive relationship was not detected between bcl-2 expression with other prognostic factors and cathepsin D protein, while a strong positive relationship was detected between bcl-2 expression with low nuclear grade and progesterone receptor¡¯ status. A strong correlation was not observed between cathepsin D expression with oestrogen receptor¡¯ status and progesterone receptor¡¯ status and c-erbB-2 oncogene amplification and other prognostic factors, while a strong correlation was also observed between cathepsin D expression with high nuclear grade and blood vessel invasion and lymph-vessel invasion and perineural invasion. Conclusion: Bcl-2 is thought to be important in determining of invasive ductal carcinoma cases with low grade, while cathepsin D is thought to be important in determining of invasive ductal carcinoma cases with high grade and invasion ability
%K £¿nvaziv duktal karsinom
%K bcl-2
%K katepsin D
%K £¿mmunhistokimya
%U http://dergipark.org.tr/bmedj/issue/40326/458146