%0 Journal Article
%T The Effects of Isotretinoin on Menstrual Cycle and Hormone Levels
%A Fidan Bener
%J -
%D 2018
%X Introduct£¿on: This study aimed at examining the effects of isotretinoin treatment on menstrual cycle and serum hormones in women with acne vulgaris. Materials and methods: In this retrospective study, the data of female patients who have been treated with isotretinoin for acne vulgaris, had regular menstrual cycles before treatment, had normal laboratory parameters, had no any systemic disease and did not take any medicine have been examined. Results: The mean age of the 21 women included in the study was 22¡À3.87. The cumulative dose of isotretinoin administered to the patient was 123.90¡À4.71 mg/kg. During the treatment, in 19.1% of the patients dehydroepiandrosterone sulfate (DHEAS), in 23.8% of free testosterone (fT) and in 33.3% of total testosterone (tT) were reported to be higher than the reference range of serum levels. There was a statistically insignificant increase in mean DHEAS and fT levels (p>0.05) compared to before treatment. During the treatment, a statistically significant in mean thyroid stimulating hormone (TSH) values (p<0.05) and a insignificant in mean free T3 (fT3) values (p>0.05) was determined progressive decrease between normal limits. There was no significant difference in mean values of 17-hydroxyprogesterone, tT, prolactin, follicle stimulating hormone, luteinizing hormone and free T4 (p>0.05). We found that 23.8% of the patients had menstrual irregularity. In one patient polymenorrhea was observed and hypomenorrhea in another one. Also, oligomenorrhea was observed in three patient, with one of them hemorrhage in the middle of her cycle. It has been determined that there is no change in the hormone levels of patients with menstrual irregularity. Conclusion: In this study show that isotretinoin has an effect on androgen metabolism, on thyroid hormones and on menstrual cycles. For this reason, we recommend follow-up in terms of hyperandrogenism and hypothyroidism in long-term treatment. As a result of the data, it can be said that abnormal uterine bleeding is not hormonal origin. Further studies are needed to prove what kind of mechanism cause these effects
%K Akne vulgaris
%K izotretinoin
%K serum hormonlar£¿
%K menstr¨¹el siklus
%U http://dergipark.org.tr/aeahtd/issue/40776/450670