%0 Journal Article
%T Fosfomycin and Nitrofurantoin Susceptibilities of Escherichia coli and Klebsiella pneumoniae Isolates Producing Extanded Spectrum Beta-lactamase Causing Urinary Tract Infections
%A UMUT SAF£¿YE £¿AY CO£¿KUN
%J -
%D 2019
%X Aim: The most common causative agents of urinary tract infections are Esherichia coli and Klebsiella pneumoniae. Increasing numbers of extanded spectrum beta-lactamase producing £¿isolates led to the search for alternative antibiotics in the treatment of urinary tract infections caused by Esherichia coli and Klebsiella pneumoniae isolates producing extanded spectrum beta-lactamase. This studies aim is to determine the sensitivity of fosfomycin and nitrofurantoin to extanded spectrum beta-lactamase producing Esherichia coli and Klebsiella pneumoniae isolates, which are defined by patients in our hospital, to contribute to the planning of empirical treatment of these patients. Matheryals and Methods: Patients urinary specimens from various services and intensive care unit were evaluated retrospectively. Identification of isolates and antibiotic susceptibility were evaluated with the VITEK 2 ID (bioM¨¦rieux, France) automatization system. Results: Extended spectrum ¦Â-lactamase producing 85 Esherichia coli and 23 Klebsiella pneumoniae were included in the study. The isolates were identified from the most frequent cases from the intensive care unit (43.5 %). The most sensitive antibiotics are carbapenems. Susceptibility rates to Esherichia coli and Klebsiella pneumoniae isolates were respectively 100% and 87% to carbapenems followed by 98% and 83% to fosfomycin 94% and 30.4% to nitrofurantoin. Conclusions: Fosfomycin is seen as a good alternative agent in urinary tract infections caused by extanded spectrum beta-lactamase producing Esherichia coli and Klebsiella pneumoniae isolates in our hospital for emprical treatment
%K Esherichia coli
%K Klebsiella pneumoniae
%K geni£¿lemi£¿ spektrumlu beta-laktamaz
%K fosfomisin
%U http://dergipark.org.tr/gopctd/issue/44052/450476