%0 Journal Article
%T Antimicrobial Activity and Cytotoxicity of Alkanna Tinctoria (L.) Tausch Root Extracts
%A Fatma Ceren ANLAS
%A Filiz UCAN TURKMEN
%A Fulya USTUN ALKAN
%A Hatice Aysun MERC£¿MEK TAKCI
%A Naz£¿m SEKEROGLU
%A Pemra BAKIRHAN
%J -
%D 2019
%X Alkanna tinctoria (L.) Tausch produced naphthoquinones known as DNA-topoisomerases inhibitors has been used as the traditional therapeutic agent, especially wound healing in Turkey. The antimicrobial activity against 9 clinical microorganisms and cytotoxicity on canine mammary carcinoma cell line (CMT-U27) of Alkanna tinctoria root extracts (methanol, ethanol and acetonitrile) were researched by using MTT analysis. Alkanet root extracts showed antimicrobial activity against 2 (Proteus spp. and S. haemolyticus) out of 9 microorganisms. In vitro study towards CMT-U27 cancer cells, acetonitrile root extract at 100 ¦Ìg/mL concentration showed strong and significant anti-proliferative effect. Our results are manifested that the Alkanet acetonitrile root extract can be evaluated as potential therapeutic agent, immediately after identification of bio-active metabolits in extract
%K Alkanat k£¿k
%K Alkanna tinctoria
%K antimikrobiyal
%K sitotoksisite
%U http://dergipark.org.tr/kfbd/issue/45378/566276