%0 Journal Article
%T Comparison ratios of two different sequential treatments for Helicobacter pylori eradication
%A Aysun G£¿nderen
%J -
%D 2019
%X Purpose: Helicobacter Pylori (HP) is a gram (-) microaerophilic bacterium that related with peptic ulcer and gastric cancer. The aim of this study was to compare the efficacy of the two different eradication therapies. Material and Methods: 98 patients were included in the study who was admitted to Gastroenterology and Internal Medicine outpatient clinics of D£¿£¿kap£¿ Y£¿ld£¿r£¿m Beyaz£¿t Training and Research Hospital with complaints of reflux, nausea, vomiting or gastric pain and had detected HP positive immunohistochemically also had not received any eradication treatment before. The patients were randomly divided into two groups. The first group was treated with omeprazole and amoxicillin in the first week then with omeprazole and metronidazole in the second week. The second group was treated with omeprazole and amoxicillin in the first week and then with omeprazole, metronidazole and tetracycline in the second week. After the treatment, control endoscopy was performed and the biopsies were taken to determine the eradication ratios. Results: The eradication ratio of treatment in the first group was 32.4% and 59.6% in the second group. There was a statistically significant difference between the eradication ratios of the groups (p<0.001). Conclusion: The eradication ratio was higher in the tetracycline-receiving treatment group however, the eradication ratios of both groups were found to be lower than the ratio of 80% that revealed in the literature. Low eradication ratio of the treatments in this study may be associated with antibiotic resistance. According to this study¡¯s results alternative treatments are needed in HP eradication
%K Helikobakter pilori
%K peptik ¨¹lser
%K tedavi
%U http://dergipark.org.tr/aeahtd/issue/47489/541104