%0 Journal Article
%T Association analysis between A163G and T245G gene polymorphisms of osteoprotegerin and bone mineral density in Turkish postmenopausal women
%A Orkide PALABIYIK
%J -
%D 2018
%X Objectives: Osteoprotegerin (OPG) is a gene which is accepted as one of the leading factor causing osteoporosis. Evaluation of the relationship between bone mineral density (BMD) and two polymorphisms in the OPG promoter, namely A163G and T245G among postmenopausal women was the goal of this study. Material and methods: A total of 194 women, 109 with postmenopausal osteoporosis and 85 healthy controls, were included in the study. Dual-energy X-ray absorptiometry was used to evaluate BMD of L1, L4, total lumbar spine (L1-4), neck, hip and total hip. A163G and T245G polymorphisms were determined by PCR and RFLP. Results: The frequencies of genotypes were as follows: AG+GG (46.8%), AA (53.2%) for A163G and GG+TG (36.7%), TT (63.3%) for T245G. Compared to healthy women, remarkably more women with osteoporosis were found to have AG+GG (p=0.005) and GG+TG (p=0.049). Significant associations were observed between the genotypes and BMD of the lumbar spine for the T245G and A163G polymorphisms in postmenopausal women and controls (p£¿0.05 for all). The GG+TG genotypes correlated with lower BMD compared to TT for T245G. Similarly, for A163G, the AG+GG genotypes were related to in smaller amounts BMD compared to AA. Conclusion: The study findings indicate that genetic arrangement of BMD can be contributed by the T245G and A163G polymorphisms in the OPG promoter. These results are expected to be beneficial for further studies investigating the role of OPG in osteoporosis
%K Osteoprotegerin
%K osteoporoz
%K gen polimorfizmi
%K kemik mineral yo£¿unlu£¿u
%U http://dergipark.org.tr/baktipd/issue/41924/499761