%0 Journal Article
%T Ischemia-modified albumin levels in patients with peptic ulcer
%A Ferdane Sapmaz
%J -
%D 2018
%X Background and Aims: Ischemia-modified albumin is a recently introduced marker in the evaluation of ischemia and oxidative stress. The aims of this study are to measure serum levels of ischemia-modified albumin before and after treatment in patients with peptic ulcer disease, to calculate the ischemia-modified albumin to albumin ratio, and to compare these values to those from the control group. Materials and Methods: Between November 2016 and April 2017, 32 patients who underwent upper gastrointestinal system endoscopy for any reason, and were found to have peptic ulcers were included in the study, along with 28 healthy controls. Some patients who had Helicobacter pylori as a result of biopsy recieved eradication therapy, while others were treated with antisecretory therapy. Ischemia-modified albumin levels in both the patient and control groups before and after treatment were measured spectrophotometrically, and ischemia-modified albumin to albumin ratios were calculated. Results: There was no statistically significant difference observed in the age and sex distributions between the patient and control groups. The mean ischemia-modified albumin value in the peptic ulcer patient group was 0.19¡À0.49 absorbance units, and the mean ischemia-modified albumin to albumin ratio was 0.42¡À0.11. The mean ischemia-modified albumin value in the control group was 0.45¡À0.16 absorbance units, and the mean ischemia-modified albumin to albumin ratio was 0.11¡À0.40. The difference was statistically significant (p <0.0001). After treatment in the peptic ulcer patient group, ischemia-modified albumin level was 0.20¡À0.72 absorbance units and ischemia-modified albumin to albumin ratio as 0.45¡À0.17. When the post-treatment values were compared with values from the control group, the difference was statistically significant (p <0.0001). When pre-treatment values were compared to post-treatment values, statistically significant difference was not observed. Conclusion: Ischemia-modified albumin level and ischemia-modified albumin to albumin ratio, both indicators of oxidative stress, are elevated in patients with peptic ulcer post-treatment
%K £¿skemi modifiye albumin
%K peptik ¨¹lser
%U http://dergipark.org.tr/agd/issue/39925/462657